Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

This study shows an experimental spillover infection ofSigmodontinae rodents with Rio Mamore hantavirus (RIOMV).Necromys lasiurus and Akodon sp were infected with 10(3) RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days aft...

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Detalles Bibliográficos
Autores principales: de Souza, William Marciel, Machado, Alex Martins, Figueiredo, Luiz Tadeu Moraes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909039/
https://www.ncbi.nlm.nih.gov/pubmed/27223653
http://dx.doi.org/10.1590/0074-02760160021
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author de Souza, William Marciel
Machado, Alex Martins
Figueiredo, Luiz Tadeu Moraes
author_facet de Souza, William Marciel
Machado, Alex Martins
Figueiredo, Luiz Tadeu Moraes
author_sort de Souza, William Marciel
collection PubMed
description This study shows an experimental spillover infection ofSigmodontinae rodents with Rio Mamore hantavirus (RIOMV).Necromys lasiurus and Akodon sp were infected with 10(3) RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.
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spelling pubmed-49090392016-06-16 Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents de Souza, William Marciel Machado, Alex Martins Figueiredo, Luiz Tadeu Moraes Mem Inst Oswaldo Cruz Short Communication This study shows an experimental spillover infection ofSigmodontinae rodents with Rio Mamore hantavirus (RIOMV).Necromys lasiurus and Akodon sp were infected with 10(3) RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals. Instituto Oswaldo Cruz, Ministério da Saúde 2016-06 /pmc/articles/PMC4909039/ /pubmed/27223653 http://dx.doi.org/10.1590/0074-02760160021 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
de Souza, William Marciel
Machado, Alex Martins
Figueiredo, Luiz Tadeu Moraes
Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_full Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_fullStr Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_full_unstemmed Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_short Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_sort experimental infection of rio mamore hantavirus in sigmodontinae rodents
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909039/
https://www.ncbi.nlm.nih.gov/pubmed/27223653
http://dx.doi.org/10.1590/0074-02760160021
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