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Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway
Methane produced by the methanoarchaeon Methanobrevibacter smithii ( M. smithii) has been linked to constipation, irritable bowel syndrome with constipation (IBS-C), and obesity. Lovastatin, which demonstrates a cholesterol-lowering effect by the inhibition of HMG-CoA reductase, may also have an ant...
Autores principales: | Muskal, Steven M., Sliman, Joe, Kokai-Kun, John, Pimentel, Mark, Wacher, Vince, Gottlieb, Klaus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909102/ https://www.ncbi.nlm.nih.gov/pubmed/27347377 http://dx.doi.org/10.12688/f1000research.8406.3 |
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