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Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation

E3 ligases represent an important class of enzymes, yet there are currently no chemical probes to profile their activity. We develop a new class of activity-based probe by reengineering of a ubiquitin-charged E2 conjugating enzyme and demonstrate their utility by profiling the transthiolation activi...

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Detalles Bibliográficos
Autores principales:	Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T., Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M.K., Virdee, Satpal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909137/ https://www.ncbi.nlm.nih.gov/pubmed/26928937 http://dx.doi.org/10.1038/nchembio.2045

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