Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris

Pemphigus vulgaris (PV) is characterized by IgG1 and IgG4 autoantibodies to desmoglein (Dsg) 3, causing suprabasal blistering of skin and mucous membranes. IgG4 is the dominant autoantibody subclass in PV and correlates with disease activity, whereas IgG1 can be associated with remittent disease. It...

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Detalles Bibliográficos
Autores principales: Lo, Agnes S., Mao, Xuming, Mukherjee, Eric M., Ellebrecht, Christoph T., Yu, Xiaocong, Posner, Marshall R., Payne, Aimee S., Cavacini, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909199/
https://www.ncbi.nlm.nih.gov/pubmed/27304671
http://dx.doi.org/10.1371/journal.pone.0156800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909199/
https://www.ncbi.nlm.nih.gov/pubmed/27304671
http://dx.doi.org/10.1371/journal.pone.0156800

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