Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function

Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin, guiding substrates, and by inducing allosteri...

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Detalles Bibliográficos
Autores principales: Yeh, Calvin H., Stafford, Alan R., Leslie, Beverly A., Fredenburgh, James C., Weitz, Jeffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909201/
https://www.ncbi.nlm.nih.gov/pubmed/27305147
http://dx.doi.org/10.1371/journal.pone.0157471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909201/
https://www.ncbi.nlm.nih.gov/pubmed/27305147
http://dx.doi.org/10.1371/journal.pone.0157471

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