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Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis
BACKGROUND AND OBJECTIVE: Surgery carries the best hope for cure in the treatment of cholangiocarcinoma (CC), whereas surgical outcome is not fully satisfactory. Bio-molecular markers have been used to improve tumor staging and prognosis prediction. Mucin antigen MUC4 (MUC4) has been implicated as a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909222/ https://www.ncbi.nlm.nih.gov/pubmed/27305093 http://dx.doi.org/10.1371/journal.pone.0157878 |
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author | Li, Bingmin Tang, Haowen Zhang, Aiqun Dong, Jiahong |
author_facet | Li, Bingmin Tang, Haowen Zhang, Aiqun Dong, Jiahong |
author_sort | Li, Bingmin |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Surgery carries the best hope for cure in the treatment of cholangiocarcinoma (CC), whereas surgical outcome is not fully satisfactory. Bio-molecular markers have been used to improve tumor staging and prognosis prediction. Mucin antigen MUC4 (MUC4) has been implicated as a marker for poor survival in various tumors. However, prognostic significance of MUC4 for patients with CC remains undefined. The aim of the present meta-analysis was to investigate the association between MUC4 expression and overall survival (OS) of patients with resected CC. METHODS: The meta-analysis was conducted in adherence to the MOOSE guidelines. PubMed, Embase databases, Cochrane Library and the Chinese SinoMed were systematically searched to identify eligible studies from the initiation of the databases to April, 2016. OSs were pooled by using hazard ratio (HR) with corresponding 95% confidence interval (CI). Random effect models were utilized because of the between-study heterogeneities. RESULTS: Five studies reporting on 249 patients were analyzed: 94 (37.75%) were in positive or high expression group and 155 (62.25%) in negative or low expression group. The pooled HR for positive or high expression group was found to be 3.04 (95% CI 2.25–4.12) when compared with negative or low expression group with slight between-study heterogeneities (I(2) 3.10%, P = 0.39). The result indicated that a positive or high expression level of MUC4 was significantly related to poor survival in patients with resected CC. A commensurate result was identified by sensitivity analysis. The main limitations of the present meta-analysis were the rather small size of the studies included and relatively narrow geographical distribution of population. CONCLUSION: The result of this meta-analysis indicated that a positive or high expression level of MUC4 was significantly related to poor survival in patients with resected CC. |
format | Online Article Text |
id | pubmed-4909222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49092222016-07-06 Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis Li, Bingmin Tang, Haowen Zhang, Aiqun Dong, Jiahong PLoS One Research Article BACKGROUND AND OBJECTIVE: Surgery carries the best hope for cure in the treatment of cholangiocarcinoma (CC), whereas surgical outcome is not fully satisfactory. Bio-molecular markers have been used to improve tumor staging and prognosis prediction. Mucin antigen MUC4 (MUC4) has been implicated as a marker for poor survival in various tumors. However, prognostic significance of MUC4 for patients with CC remains undefined. The aim of the present meta-analysis was to investigate the association between MUC4 expression and overall survival (OS) of patients with resected CC. METHODS: The meta-analysis was conducted in adherence to the MOOSE guidelines. PubMed, Embase databases, Cochrane Library and the Chinese SinoMed were systematically searched to identify eligible studies from the initiation of the databases to April, 2016. OSs were pooled by using hazard ratio (HR) with corresponding 95% confidence interval (CI). Random effect models were utilized because of the between-study heterogeneities. RESULTS: Five studies reporting on 249 patients were analyzed: 94 (37.75%) were in positive or high expression group and 155 (62.25%) in negative or low expression group. The pooled HR for positive or high expression group was found to be 3.04 (95% CI 2.25–4.12) when compared with negative or low expression group with slight between-study heterogeneities (I(2) 3.10%, P = 0.39). The result indicated that a positive or high expression level of MUC4 was significantly related to poor survival in patients with resected CC. A commensurate result was identified by sensitivity analysis. The main limitations of the present meta-analysis were the rather small size of the studies included and relatively narrow geographical distribution of population. CONCLUSION: The result of this meta-analysis indicated that a positive or high expression level of MUC4 was significantly related to poor survival in patients with resected CC. Public Library of Science 2016-06-15 /pmc/articles/PMC4909222/ /pubmed/27305093 http://dx.doi.org/10.1371/journal.pone.0157878 Text en © 2016 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Bingmin Tang, Haowen Zhang, Aiqun Dong, Jiahong Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title | Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title_full | Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title_fullStr | Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title_full_unstemmed | Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title_short | Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis |
title_sort | prognostic role of mucin antigen muc4 for cholangiocarcinoma: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909222/ https://www.ncbi.nlm.nih.gov/pubmed/27305093 http://dx.doi.org/10.1371/journal.pone.0157878 |
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