Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult. Via matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to localize renal nucleotides we f...

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Detalles Bibliográficos
Autores principales: Miyamoto, Satoshi, Hsu, Cheng-Chih, Hamm, Gregory, Darshi, Manjula, Diamond-Stanic, Maggie, Declèves, Anne-Emilie, Slater, Larkin, Pennathur, Subramaniam, Stauber, Jonathan, Dorrestein, Pieter C., Sharma, Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909366/
https://www.ncbi.nlm.nih.gov/pubmed/27322466
http://dx.doi.org/10.1016/j.ebiom.2016.03.033

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