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Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila

Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present...

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Autores principales: Liu, Qingqing, Yang, Xing, Tian, Jingsong, Gao, Zhongbao, Wang, Meng, Li, Yan, Guo, Aike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909397/
https://www.ncbi.nlm.nih.gov/pubmed/27218450
http://dx.doi.org/10.7554/eLife.13238
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author Liu, Qingqing
Yang, Xing
Tian, Jingsong
Gao, Zhongbao
Wang, Meng
Li, Yan
Guo, Aike
author_facet Liu, Qingqing
Yang, Xing
Tian, Jingsong
Gao, Zhongbao
Wang, Meng
Li, Yan
Guo, Aike
author_sort Liu, Qingqing
collection PubMed
description Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly’s visual learning and memory. DOI: http://dx.doi.org/10.7554/eLife.13238.001
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spelling pubmed-49093972016-06-16 Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila Liu, Qingqing Yang, Xing Tian, Jingsong Gao, Zhongbao Wang, Meng Li, Yan Guo, Aike eLife Neuroscience Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly’s visual learning and memory. DOI: http://dx.doi.org/10.7554/eLife.13238.001 eLife Sciences Publications, Ltd 2016-05-24 /pmc/articles/PMC4909397/ /pubmed/27218450 http://dx.doi.org/10.7554/eLife.13238 Text en © 2016, Liu et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Liu, Qingqing
Yang, Xing
Tian, Jingsong
Gao, Zhongbao
Wang, Meng
Li, Yan
Guo, Aike
Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title_full Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title_fullStr Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title_full_unstemmed Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title_short Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
title_sort gap junction networks in mushroom bodies participate in visual learning and memory in drosophila
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909397/
https://www.ncbi.nlm.nih.gov/pubmed/27218450
http://dx.doi.org/10.7554/eLife.13238
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