Tumor suppression by stromal TIMPs

The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and...

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Detalles Bibliográficos
Autores principales: Shimoda, Masayuki, Jackson, Hartland W., Khokha, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909426/
https://www.ncbi.nlm.nih.gov/pubmed/27314104
http://dx.doi.org/10.4161/23723556.2014.975082
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author Shimoda, Masayuki
Jackson, Hartland W.
Khokha, Rama
author_facet Shimoda, Masayuki
Jackson, Hartland W.
Khokha, Rama
author_sort Shimoda, Masayuki
collection PubMed
description The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal–tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes.
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spelling pubmed-49094262017-03-30 Tumor suppression by stromal TIMPs Shimoda, Masayuki Jackson, Hartland W. Khokha, Rama Mol Cell Oncol Author's View The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal–tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes. Taylor & Francis 2016-03-30 /pmc/articles/PMC4909426/ /pubmed/27314104 http://dx.doi.org/10.4161/23723556.2014.975082 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Shimoda, Masayuki
Jackson, Hartland W.
Khokha, Rama
Tumor suppression by stromal TIMPs
title Tumor suppression by stromal TIMPs
title_full Tumor suppression by stromal TIMPs
title_fullStr Tumor suppression by stromal TIMPs
title_full_unstemmed Tumor suppression by stromal TIMPs
title_short Tumor suppression by stromal TIMPs
title_sort tumor suppression by stromal timps
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909426/
https://www.ncbi.nlm.nih.gov/pubmed/27314104
http://dx.doi.org/10.4161/23723556.2014.975082
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