The paradox of dicer in cancer

Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the conte...

Descripción completa

Detalles Bibliográficos
Autores principales: Swahari, Vijay, Nakamura, Ayumi, Deshmukh, Mohanish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909435/
https://www.ncbi.nlm.nih.gov/pubmed/27314098
http://dx.doi.org/10.1080/23723556.2016.1155006
Descripción
Sumario:Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage response.

Ejemplares similares