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Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with pro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909457/ https://www.ncbi.nlm.nih.gov/pubmed/27314086 http://dx.doi.org/10.1080/23723556.2015.1046582 |
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author | Liu, Bodu Sun, Lijuan Song, Erwei |
author_facet | Liu, Bodu Sun, Lijuan Song, Erwei |
author_sort | Liu, Bodu |
collection | PubMed |
description | We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs. |
format | Online Article Text |
id | pubmed-4909457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-49094572017-03-16 Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways Liu, Bodu Sun, Lijuan Song, Erwei Mol Cell Oncol Author's View We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs. Taylor & Francis 2016-03-16 /pmc/articles/PMC4909457/ /pubmed/27314086 http://dx.doi.org/10.1080/23723556.2015.1046582 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Author's View Liu, Bodu Sun, Lijuan Song, Erwei Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title | Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title_full | Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title_fullStr | Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title_full_unstemmed | Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title_short | Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways |
title_sort | pinched by rna “fingers”: long noncoding rnas hitting signal transduction pathways |
topic | Author's View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909457/ https://www.ncbi.nlm.nih.gov/pubmed/27314086 http://dx.doi.org/10.1080/23723556.2015.1046582 |
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