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Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways

We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with pro...

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Detalles Bibliográficos
Autores principales: Liu, Bodu, Sun, Lijuan, Song, Erwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909457/
https://www.ncbi.nlm.nih.gov/pubmed/27314086
http://dx.doi.org/10.1080/23723556.2015.1046582
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author Liu, Bodu
Sun, Lijuan
Song, Erwei
author_facet Liu, Bodu
Sun, Lijuan
Song, Erwei
author_sort Liu, Bodu
collection PubMed
description We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs.
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spelling pubmed-49094572017-03-16 Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways Liu, Bodu Sun, Lijuan Song, Erwei Mol Cell Oncol Author's View We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs. Taylor & Francis 2016-03-16 /pmc/articles/PMC4909457/ /pubmed/27314086 http://dx.doi.org/10.1080/23723556.2015.1046582 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Liu, Bodu
Sun, Lijuan
Song, Erwei
Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title_full Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title_fullStr Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title_full_unstemmed Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title_short Pinched by RNA “fingers”: Long noncoding RNAs hitting signal transduction pathways
title_sort pinched by rna “fingers”: long noncoding rnas hitting signal transduction pathways
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909457/
https://www.ncbi.nlm.nih.gov/pubmed/27314086
http://dx.doi.org/10.1080/23723556.2015.1046582
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