Genotype-guided tacrolimus dosing in African American kidney transplant recipients

Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AA) have on average higher tacrolimus dose requirements than Caucasians; however, some have requirements s...

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Detalles Bibliográficos
Autores principales: Sanghavi, K., Brundage, RC., Miller, MB., Schladt, DP., Israni, AK., Guan, W., Oettin, WS., Mannon, RB., Remme, RP., Matas, AJ., Jacobson, PA.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909584/
https://www.ncbi.nlm.nih.gov/pubmed/26667830
http://dx.doi.org/10.1038/tpj.2015.87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909584/
https://www.ncbi.nlm.nih.gov/pubmed/26667830
http://dx.doi.org/10.1038/tpj.2015.87

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