The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer

The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histolo...

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Autores principales: Van der Roest, Rosanne CV., van Houdt, Petra J., Heijmink, Stijn WTPJ., de Jong, Jeroen, Bergman, André M., Zwart, Wilbert, van der Heide, Uulke A., van der Poel, Henk G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909636/
https://www.ncbi.nlm.nih.gov/pubmed/27335799
http://dx.doi.org/10.1016/j.eucr.2016.04.010
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author Van der Roest, Rosanne CV.
van Houdt, Petra J.
Heijmink, Stijn WTPJ.
de Jong, Jeroen
Bergman, André M.
Zwart, Wilbert
van der Heide, Uulke A.
van der Poel, Henk G.
author_facet Van der Roest, Rosanne CV.
van Houdt, Petra J.
Heijmink, Stijn WTPJ.
de Jong, Jeroen
Bergman, André M.
Zwart, Wilbert
van der Heide, Uulke A.
van der Poel, Henk G.
author_sort Van der Roest, Rosanne CV.
collection PubMed
description The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide resulted in an increase in ADC value on the DWI-MRI sequences. Histological changes were also observed.
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spelling pubmed-49096362016-06-22 The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer Van der Roest, Rosanne CV. van Houdt, Petra J. Heijmink, Stijn WTPJ. de Jong, Jeroen Bergman, André M. Zwart, Wilbert van der Heide, Uulke A. van der Poel, Henk G. Urol Case Rep Oncology The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide resulted in an increase in ADC value on the DWI-MRI sequences. Histological changes were also observed. Elsevier 2016-05-26 /pmc/articles/PMC4909636/ /pubmed/27335799 http://dx.doi.org/10.1016/j.eucr.2016.04.010 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Van der Roest, Rosanne CV.
van Houdt, Petra J.
Heijmink, Stijn WTPJ.
de Jong, Jeroen
Bergman, André M.
Zwart, Wilbert
van der Heide, Uulke A.
van der Poel, Henk G.
The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title_full The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title_fullStr The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title_full_unstemmed The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title_short The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer
title_sort effects of enzalutamide monotherapy on multiparametric 3t mr imaging in prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909636/
https://www.ncbi.nlm.nih.gov/pubmed/27335799
http://dx.doi.org/10.1016/j.eucr.2016.04.010
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