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Recent developments in using mechanistic cardiac modelling for drug safety evaluation

On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive...

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Detalles Bibliográficos
Autores principales:	Davies, Mark R., Wang, Ken, Mirams, Gary R., Caruso, Antonello, Noble, Denis, Walz, Antje, Lavé, Thierry, Schuler, Franz, Singer, Thomas, Polonchuk, Liudmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd. ;, Distributed by Virgin Mailing and Distribution 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909717/ https://www.ncbi.nlm.nih.gov/pubmed/26891981 http://dx.doi.org/10.1016/j.drudis.2016.02.003

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