Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide

Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated w...

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Autores principales: Somerville, Lucy K., Henderson, Andrew P., Chen, Sharon C.A., Kok, Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909863/
https://www.ncbi.nlm.nih.gov/pubmed/27330941
http://dx.doi.org/10.1016/j.mmcr.2014.12.003
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author Somerville, Lucy K.
Henderson, Andrew P.
Chen, Sharon C.A.
Kok, Jen
author_facet Somerville, Lucy K.
Henderson, Andrew P.
Chen, Sharon C.A.
Kok, Jen
author_sort Somerville, Lucy K.
collection PubMed
description Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated with thalidomide following failure of corticosteroid therapy. Data on thalidomide use in cryptococcal IRIS are awaited.
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spelling pubmed-49098632016-06-21 Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide Somerville, Lucy K. Henderson, Andrew P. Chen, Sharon C.A. Kok, Jen Med Mycol Case Rep Case Report Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated with thalidomide following failure of corticosteroid therapy. Data on thalidomide use in cryptococcal IRIS are awaited. Elsevier 2014-12-20 /pmc/articles/PMC4909863/ /pubmed/27330941 http://dx.doi.org/10.1016/j.mmcr.2014.12.003 Text en Crown Copyright © 2014 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Somerville, Lucy K.
Henderson, Andrew P.
Chen, Sharon C.A.
Kok, Jen
Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_full Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_fullStr Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_full_unstemmed Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_short Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_sort successful treatment of cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909863/
https://www.ncbi.nlm.nih.gov/pubmed/27330941
http://dx.doi.org/10.1016/j.mmcr.2014.12.003
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AT chensharonca successfultreatmentofcryptococcusneoformansimmunereconstitutioninflammatorysyndromeinanimmunocompetenthostusingthalidomide
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