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NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909917/ https://www.ncbi.nlm.nih.gov/pubmed/27340506 http://dx.doi.org/10.1155/2016/2746457 |
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author | Kim, Jaieun Keum, Young-Sam |
author_facet | Kim, Jaieun Keum, Young-Sam |
author_sort | Kim, Jaieun |
collection | PubMed |
description | While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. While the NRF2 activity has been generally viewed as beneficial to preserve the integrity of organisms, recent studies have demonstrated that cancer cells hijack the NRF2 activity to survive under the oxidative stress and, therefore, a close check must be kept on the NRF2 activity in cancer. In the present review, we briefly highlight important progresses in understanding the molecular mechanism, structure, and function of KEAP1 and NRF2 interaction. In addition, we provide general perspectives that justify conflicting views on the NRF2 activity in cancer. |
format | Online Article Text |
id | pubmed-4909917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49099172016-06-23 NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Kim, Jaieun Keum, Young-Sam Oxid Med Cell Longev Review Article While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. While the NRF2 activity has been generally viewed as beneficial to preserve the integrity of organisms, recent studies have demonstrated that cancer cells hijack the NRF2 activity to survive under the oxidative stress and, therefore, a close check must be kept on the NRF2 activity in cancer. In the present review, we briefly highlight important progresses in understanding the molecular mechanism, structure, and function of KEAP1 and NRF2 interaction. In addition, we provide general perspectives that justify conflicting views on the NRF2 activity in cancer. Hindawi Publishing Corporation 2016 2016-06-02 /pmc/articles/PMC4909917/ /pubmed/27340506 http://dx.doi.org/10.1155/2016/2746457 Text en Copyright © 2016 J. Kim and Y.-S. Keum. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Jaieun Keum, Young-Sam NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title_full | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title_fullStr | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title_full_unstemmed | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title_short | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
title_sort | nrf2, a key regulator of antioxidants with two faces towards cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909917/ https://www.ncbi.nlm.nih.gov/pubmed/27340506 http://dx.doi.org/10.1155/2016/2746457 |
work_keys_str_mv | AT kimjaieun nrf2akeyregulatorofantioxidantswithtwofacestowardscancer AT keumyoungsam nrf2akeyregulatorofantioxidantswithtwofacestowardscancer |