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NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxi...

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Detalles Bibliográficos
Autores principales: Kim, Jaieun, Keum, Young-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909917/
https://www.ncbi.nlm.nih.gov/pubmed/27340506
http://dx.doi.org/10.1155/2016/2746457
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author Kim, Jaieun
Keum, Young-Sam
author_facet Kim, Jaieun
Keum, Young-Sam
author_sort Kim, Jaieun
collection PubMed
description While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. While the NRF2 activity has been generally viewed as beneficial to preserve the integrity of organisms, recent studies have demonstrated that cancer cells hijack the NRF2 activity to survive under the oxidative stress and, therefore, a close check must be kept on the NRF2 activity in cancer. In the present review, we briefly highlight important progresses in understanding the molecular mechanism, structure, and function of KEAP1 and NRF2 interaction. In addition, we provide general perspectives that justify conflicting views on the NRF2 activity in cancer.
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spelling pubmed-49099172016-06-23 NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Kim, Jaieun Keum, Young-Sam Oxid Med Cell Longev Review Article While reactive oxygen species (ROS) is generally considered harmful, a relevant amount of ROS is necessary for a number of cellular functions, including the intracellular signal transduction. In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. While the NRF2 activity has been generally viewed as beneficial to preserve the integrity of organisms, recent studies have demonstrated that cancer cells hijack the NRF2 activity to survive under the oxidative stress and, therefore, a close check must be kept on the NRF2 activity in cancer. In the present review, we briefly highlight important progresses in understanding the molecular mechanism, structure, and function of KEAP1 and NRF2 interaction. In addition, we provide general perspectives that justify conflicting views on the NRF2 activity in cancer. Hindawi Publishing Corporation 2016 2016-06-02 /pmc/articles/PMC4909917/ /pubmed/27340506 http://dx.doi.org/10.1155/2016/2746457 Text en Copyright © 2016 J. Kim and Y.-S. Keum. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Jaieun
Keum, Young-Sam
NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title_full NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title_fullStr NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title_full_unstemmed NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title_short NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
title_sort nrf2, a key regulator of antioxidants with two faces towards cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909917/
https://www.ncbi.nlm.nih.gov/pubmed/27340506
http://dx.doi.org/10.1155/2016/2746457
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