Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell carcinoma (ccRCC). Here we address the question whether ITH increases with malignant progression and can hence be exploited as a prognostic m...

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Detalles Bibliográficos
Autores principales: Hoefflin, Rouven, Lahrmann, Bernd, Warsow, Gregor, Hübschmann, Daniel, Spath, Cathleen, Walter, Britta, Chen, Xin, Hofer, Luisa, Macher-Goeppinger, Stephan, Tolstov, Yanis, Korzeniewski, Nina, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Perner, Sven, Schönberg, Gita, Nyarangi-Dix, Joanne, Isaac, Sanjay, Hatiboglu, Gencay, Teber, Dogu, Hadaschik, Boris, Pahernik, Sascha, Roth, Wilfried, Eils, Roland, Schlesner, Matthias, Sültmann, Holger, Hohenfellner, Markus, Grabe, Niels, Duensing, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910022/
https://www.ncbi.nlm.nih.gov/pubmed/27291893
http://dx.doi.org/10.1038/ncomms11845

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