58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability

Lysosome membrane permeabilization (LMP) has been implicated in cell death. In the present study, we investigated the relationship between cell death and H(2)O(2)-/CCl(4)-induced LMP in hepatocytes in vitro and following acute liver injury in vivo. The key finding was that H(2)O(2) triggered LMP by...

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Detalles Bibliográficos
Autores principales: Yan, Xiaofeng, Ye, Tingjie, Hu, Xudong, Zhao, Pei, Wang, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910050/
https://www.ncbi.nlm.nih.gov/pubmed/27306715
http://dx.doi.org/10.1038/srep27875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910050/
https://www.ncbi.nlm.nih.gov/pubmed/27306715
http://dx.doi.org/10.1038/srep27875

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