Naïve CD8(+) T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment

Despite of the potential implications for cancer immunotherapy, conventional approaches using in vitro expanded CD8(+) T cells have suboptimal outcomes, mostly due to loss of functionality from cellular exhaustion. We therefore investigated the phenotypic and functional differences among in vitro ac...

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Detalles Bibliográficos
Autores principales: Nguyen, Hong Hanh, Kim, Therasa, Song, Sang Yun, Park, Somang, Cho, Hyang Hee, Jung, Sung-Hoon, Ahn, Jae-Sook, Kim, Hyeoung-Joon, Lee, Je-Jung, Kim, Hee-Ok, Cho, Jae-Ho, Yang, Deok-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910083/
https://www.ncbi.nlm.nih.gov/pubmed/27306834
http://dx.doi.org/10.1038/srep28208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910083/
https://www.ncbi.nlm.nih.gov/pubmed/27306834
http://dx.doi.org/10.1038/srep28208

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