Naïve CD8(+) T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment

Despite of the potential implications for cancer immunotherapy, conventional approaches using in vitro expanded CD8(+) T cells have suboptimal outcomes, mostly due to loss of functionality from cellular exhaustion. We therefore investigated the phenotypic and functional differences among in vitro ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Hong Hanh, Kim, Therasa, Song, Sang Yun, Park, Somang, Cho, Hyang Hee, Jung, Sung-Hoon, Ahn, Jae-Sook, Kim, Hyeoung-Joon, Lee, Je-Jung, Kim, Hee-Ok, Cho, Jae-Ho, Yang, Deok-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910083/
https://www.ncbi.nlm.nih.gov/pubmed/27306834
http://dx.doi.org/10.1038/srep28208

Ejemplares similares

Ejemplares similares