Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder among women of childbearing age. PCOS has various and heterogeneous clinical features apart from its indefinite pathogenesis and mechanism. Clinical drugs for PCOS are multifarious because it only treats separate symptoms...

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Autores principales: Wang, Yu, Fu, Xin, Xu, Jing, Wang, Qiuhong, Kuang, Haixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910093/
https://www.ncbi.nlm.nih.gov/pubmed/27306862
http://dx.doi.org/10.1038/srep28089
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author Wang, Yu
Fu, Xin
Xu, Jing
Wang, Qiuhong
Kuang, Haixue
author_facet Wang, Yu
Fu, Xin
Xu, Jing
Wang, Qiuhong
Kuang, Haixue
author_sort Wang, Yu
collection PubMed
description Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder among women of childbearing age. PCOS has various and heterogeneous clinical features apart from its indefinite pathogenesis and mechanism. Clinical drugs for PCOS are multifarious because it only treats separate symptoms. Berberine is an isoquinoline plant alkaloid with numerous biological activities, and it was testified to improve some diseases related to PCOS in animal models and in humans. Systems pharmacology was utilized to predict the potential targets of berberine related to PCOS and the potential drug-drug interaction base on the disease network. In conclusion, berberine is a promising polypharmacological drug for treating PCOS, and for enhancing the efficacy of clinical drugs.
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spelling pubmed-49100932016-06-16 Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome Wang, Yu Fu, Xin Xu, Jing Wang, Qiuhong Kuang, Haixue Sci Rep Article Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder among women of childbearing age. PCOS has various and heterogeneous clinical features apart from its indefinite pathogenesis and mechanism. Clinical drugs for PCOS are multifarious because it only treats separate symptoms. Berberine is an isoquinoline plant alkaloid with numerous biological activities, and it was testified to improve some diseases related to PCOS in animal models and in humans. Systems pharmacology was utilized to predict the potential targets of berberine related to PCOS and the potential drug-drug interaction base on the disease network. In conclusion, berberine is a promising polypharmacological drug for treating PCOS, and for enhancing the efficacy of clinical drugs. Nature Publishing Group 2016-06-16 /pmc/articles/PMC4910093/ /pubmed/27306862 http://dx.doi.org/10.1038/srep28089 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Yu
Fu, Xin
Xu, Jing
Wang, Qiuhong
Kuang, Haixue
Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title_full Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title_fullStr Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title_full_unstemmed Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title_short Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
title_sort systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910093/
https://www.ncbi.nlm.nih.gov/pubmed/27306862
http://dx.doi.org/10.1038/srep28089
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