Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation)

A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 in...

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Detalles Bibliográficos
Autores principales: Komissarov, Andrey, Fadeev, Artem, Sergeeva, Maria, Petrov, Sergey, Sintsova, Kseniya, Egorova, Anna, Pisareva, Maria, Buzitskaya, Zhanna, Musaeva, Tamila, Danilenko, Daria, Konovalova, Nadezhda, Petrova, Polina, Stolyarov, Kirill, Smorodintseva, Elizaveta, Burtseva, Elena, Krasnoslobodtsev, Kirill, Kirillova, Elena, Karpova, Lyudmila, Eropkin, Mikhail, Sominina, Anna, Grudinin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910175/
https://www.ncbi.nlm.nih.gov/pubmed/26992820
http://dx.doi.org/10.1111/irv.12389
Descripción
Sumario:A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole‐genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA‐X) that probably emerged before the beginning of 2015/2016 epidemic season.

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