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Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation)
A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 in...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910175/ https://www.ncbi.nlm.nih.gov/pubmed/26992820 http://dx.doi.org/10.1111/irv.12389 |
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| author | Komissarov, Andrey Fadeev, Artem Sergeeva, Maria Petrov, Sergey Sintsova, Kseniya Egorova, Anna Pisareva, Maria Buzitskaya, Zhanna Musaeva, Tamila Danilenko, Daria Konovalova, Nadezhda Petrova, Polina Stolyarov, Kirill Smorodintseva, Elizaveta Burtseva, Elena Krasnoslobodtsev, Kirill Kirillova, Elena Karpova, Lyudmila Eropkin, Mikhail Sominina, Anna Grudinin, Mikhail |
| author_facet | Komissarov, Andrey Fadeev, Artem Sergeeva, Maria Petrov, Sergey Sintsova, Kseniya Egorova, Anna Pisareva, Maria Buzitskaya, Zhanna Musaeva, Tamila Danilenko, Daria Konovalova, Nadezhda Petrova, Polina Stolyarov, Kirill Smorodintseva, Elizaveta Burtseva, Elena Krasnoslobodtsev, Kirill Kirillova, Elena Karpova, Lyudmila Eropkin, Mikhail Sominina, Anna Grudinin, Mikhail |
| author_sort | Komissarov, Andrey |
| collection | PubMed |
| description | A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole‐genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA‐X) that probably emerged before the beginning of 2015/2016 epidemic season. |
| format | Online Article Text |
| id | pubmed-4910175 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49101752016-07-01 Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) Komissarov, Andrey Fadeev, Artem Sergeeva, Maria Petrov, Sergey Sintsova, Kseniya Egorova, Anna Pisareva, Maria Buzitskaya, Zhanna Musaeva, Tamila Danilenko, Daria Konovalova, Nadezhda Petrova, Polina Stolyarov, Kirill Smorodintseva, Elizaveta Burtseva, Elena Krasnoslobodtsev, Kirill Kirillova, Elena Karpova, Lyudmila Eropkin, Mikhail Sominina, Anna Grudinin, Mikhail Influenza Other Respir Viruses Short Article A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole‐genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA‐X) that probably emerged before the beginning of 2015/2016 epidemic season. John Wiley and Sons Inc. 2016-05-27 2016-07 /pmc/articles/PMC4910175/ /pubmed/26992820 http://dx.doi.org/10.1111/irv.12389 Text en © 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Short Article Komissarov, Andrey Fadeev, Artem Sergeeva, Maria Petrov, Sergey Sintsova, Kseniya Egorova, Anna Pisareva, Maria Buzitskaya, Zhanna Musaeva, Tamila Danilenko, Daria Konovalova, Nadezhda Petrova, Polina Stolyarov, Kirill Smorodintseva, Elizaveta Burtseva, Elena Krasnoslobodtsev, Kirill Kirillova, Elena Karpova, Lyudmila Eropkin, Mikhail Sominina, Anna Grudinin, Mikhail Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title | Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title_full | Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title_fullStr | Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title_full_unstemmed | Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title_short | Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation) |
| title_sort | rapid spread of influenza a(h1n1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in moscow and saint petersburg (russian federation) |
| topic | Short Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910175/ https://www.ncbi.nlm.nih.gov/pubmed/26992820 http://dx.doi.org/10.1111/irv.12389 |
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