Cargando…

Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study

OBJECTIVE: This study investigated white matter integrity in patients with amnestic mild cognitive impairment by diffusion tensor imaging. METHODS: A total of 83 patients with amnestic mild cognitive impairment and 85 elderly healthy controls underwent neuropsychological testing and a diffusion tens...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Duan, Wang, Zan, Shu, Hao, Zhang, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910535/
https://www.ncbi.nlm.nih.gov/pubmed/27354916
http://dx.doi.org/10.1177/2050312116648812
_version_ 1782438024765767680
author Liu, Duan
Wang, Zan
Shu, Hao
Zhang, Zhijun
author_facet Liu, Duan
Wang, Zan
Shu, Hao
Zhang, Zhijun
author_sort Liu, Duan
collection PubMed
description OBJECTIVE: This study investigated white matter integrity in patients with amnestic mild cognitive impairment by diffusion tensor imaging. METHODS: A total of 83 patients with amnestic mild cognitive impairment and 85 elderly healthy controls underwent neuropsychological testing and a diffusion tensor imaging scan. Whole-brain white matter data were parcellated into 50 regions based on the anatomical ICBM-DTI-81 atlas, and regional diffusion metrics consisting of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated for each region. Diffusion tensor imaging indices were compared between groups, and it was determined that between-group differences were significantly correlated with neurocognitive performance. RESULTS: Relative to the healthy controls group, the amnestic mild cognitive impairment group exhibited poorer cognitive performance in all neuropsychological tests except the complex figure test (p = 0.083) and showed decreased mean fractional anisotropy in the fornix, increased mean diffusivity in the fornix and bilateral uncinate fasciculus, elevated axial diffusivity in the fornix and genu of corpus callosum, and elevated radial diffusivity in the fornix and bilateral uncinate fasciculus (p < 0.05). Behaviorally, integrity of the bilateral uncinate fasciculus was correlated positively with episodic memory function, while left uncinate fasciculus integrity was positively associated with language function in the amnestic mild cognitive impairment group (p < 0.05). CONCLUSION: White matter abnormalities in neural pathways associated with memory were correlated with neurocognitive deficiencies in amnestic mild cognitive impairment. Given that amnestic mild cognitive impairment is putatively a prodromal syndrome for Alzheimer’s disease, this study furthers our understanding of the white matter changes associated with Alzheimer’s disease pathogenesis in the predementia stage.
format Online
Article
Text
id pubmed-4910535
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-49105352016-06-28 Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study Liu, Duan Wang, Zan Shu, Hao Zhang, Zhijun SAGE Open Med Original Article OBJECTIVE: This study investigated white matter integrity in patients with amnestic mild cognitive impairment by diffusion tensor imaging. METHODS: A total of 83 patients with amnestic mild cognitive impairment and 85 elderly healthy controls underwent neuropsychological testing and a diffusion tensor imaging scan. Whole-brain white matter data were parcellated into 50 regions based on the anatomical ICBM-DTI-81 atlas, and regional diffusion metrics consisting of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated for each region. Diffusion tensor imaging indices were compared between groups, and it was determined that between-group differences were significantly correlated with neurocognitive performance. RESULTS: Relative to the healthy controls group, the amnestic mild cognitive impairment group exhibited poorer cognitive performance in all neuropsychological tests except the complex figure test (p = 0.083) and showed decreased mean fractional anisotropy in the fornix, increased mean diffusivity in the fornix and bilateral uncinate fasciculus, elevated axial diffusivity in the fornix and genu of corpus callosum, and elevated radial diffusivity in the fornix and bilateral uncinate fasciculus (p < 0.05). Behaviorally, integrity of the bilateral uncinate fasciculus was correlated positively with episodic memory function, while left uncinate fasciculus integrity was positively associated with language function in the amnestic mild cognitive impairment group (p < 0.05). CONCLUSION: White matter abnormalities in neural pathways associated with memory were correlated with neurocognitive deficiencies in amnestic mild cognitive impairment. Given that amnestic mild cognitive impairment is putatively a prodromal syndrome for Alzheimer’s disease, this study furthers our understanding of the white matter changes associated with Alzheimer’s disease pathogenesis in the predementia stage. SAGE Publications 2016-06-14 /pmc/articles/PMC4910535/ /pubmed/27354916 http://dx.doi.org/10.1177/2050312116648812 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Liu, Duan
Wang, Zan
Shu, Hao
Zhang, Zhijun
Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title_full Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title_fullStr Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title_full_unstemmed Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title_short Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study
title_sort disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: an atlas-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910535/
https://www.ncbi.nlm.nih.gov/pubmed/27354916
http://dx.doi.org/10.1177/2050312116648812
work_keys_str_mv AT liuduan disruptedwhitematterintegrityisassociatedwithcognitivedeficitsinpatientswithamnesticmildcognitiveimpairmentanatlasbasedstudy
AT wangzan disruptedwhitematterintegrityisassociatedwithcognitivedeficitsinpatientswithamnesticmildcognitiveimpairmentanatlasbasedstudy
AT shuhao disruptedwhitematterintegrityisassociatedwithcognitivedeficitsinpatientswithamnesticmildcognitiveimpairmentanatlasbasedstudy
AT zhangzhijun disruptedwhitematterintegrityisassociatedwithcognitivedeficitsinpatientswithamnesticmildcognitiveimpairmentanatlasbasedstudy