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The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon
Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Genética
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910557/ https://www.ncbi.nlm.nih.gov/pubmed/27192128 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0098 |
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author | Milhomem-Paixão, Susana Suely Rodrigues Fascineli, Maria Luiza Roll, Mariana Matos Longo, João Paulo Figueiró Azevedo, Ricardo Bentes Pieczarka, Julio Cesar Salgado, Hugo Leonardo Crisóstomo Santos, Alberdan Silva Grisolia, Cesar Koppe |
author_facet | Milhomem-Paixão, Susana Suely Rodrigues Fascineli, Maria Luiza Roll, Mariana Matos Longo, João Paulo Figueiró Azevedo, Ricardo Bentes Pieczarka, Julio Cesar Salgado, Hugo Leonardo Crisóstomo Santos, Alberdan Silva Grisolia, Cesar Koppe |
author_sort | Milhomem-Paixão, Susana Suely Rodrigues |
collection | PubMed |
description | Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of this oil for humans. The aim of this work was therefore to investigate the hematotoxicity, genotoxicity and mutagenicity of andiroba oil using the comet and micronucleus assays, and to assess its antioxidant properties and lipidome as a means of addressing safety issues. For the experiments, andiroba oil was administered by gavage for 14 consecutive days in nulliparous female Swiss mice randomly distributed in four groups: negative control and three doses of oil (500, 1000 and 2000 mg/kg/day). These doses were chosen based on recommendations of the OECD guideline no. 474 (1997). GC/MS was used to investigate the free fatty acid, cholesterol and triterpene content of andiroba oil in a lipidomic analysis. No clinical or behavioral alterations were observed throughout the period of treatment, and exposure to andiroba oil at the doses and conditions used here did not result in hematotoxic, genotoxic or mutagenic effects. Tests in vitro showed that oil sample 3 from southwestern of Brazilian Amazon had a high antioxidant capacity that may protect biological systems from oxidative stress, although this activity remains to be demonstrated in vivo. |
format | Online Article Text |
id | pubmed-4910557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-49105572016-07-01 The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon Milhomem-Paixão, Susana Suely Rodrigues Fascineli, Maria Luiza Roll, Mariana Matos Longo, João Paulo Figueiró Azevedo, Ricardo Bentes Pieczarka, Julio Cesar Salgado, Hugo Leonardo Crisóstomo Santos, Alberdan Silva Grisolia, Cesar Koppe Genet Mol Biol Mutagenesis Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of this oil for humans. The aim of this work was therefore to investigate the hematotoxicity, genotoxicity and mutagenicity of andiroba oil using the comet and micronucleus assays, and to assess its antioxidant properties and lipidome as a means of addressing safety issues. For the experiments, andiroba oil was administered by gavage for 14 consecutive days in nulliparous female Swiss mice randomly distributed in four groups: negative control and three doses of oil (500, 1000 and 2000 mg/kg/day). These doses were chosen based on recommendations of the OECD guideline no. 474 (1997). GC/MS was used to investigate the free fatty acid, cholesterol and triterpene content of andiroba oil in a lipidomic analysis. No clinical or behavioral alterations were observed throughout the period of treatment, and exposure to andiroba oil at the doses and conditions used here did not result in hematotoxic, genotoxic or mutagenic effects. Tests in vitro showed that oil sample 3 from southwestern of Brazilian Amazon had a high antioxidant capacity that may protect biological systems from oxidative stress, although this activity remains to be demonstrated in vivo. Sociedade Brasileira de Genética 2016-05-13 2016 /pmc/articles/PMC4910557/ /pubmed/27192128 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0098 Text en Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. |
spellingShingle | Mutagenesis Milhomem-Paixão, Susana Suely Rodrigues Fascineli, Maria Luiza Roll, Mariana Matos Longo, João Paulo Figueiró Azevedo, Ricardo Bentes Pieczarka, Julio Cesar Salgado, Hugo Leonardo Crisóstomo Santos, Alberdan Silva Grisolia, Cesar Koppe The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon |
title | The lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the Brazilian Amazon |
title_full | The lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the Brazilian Amazon |
title_fullStr | The lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the Brazilian Amazon |
title_full_unstemmed | The lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the Brazilian Amazon |
title_short | The lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the Brazilian Amazon |
title_sort | lipidome, genotoxicity, hematotoxicity and antioxidant properties of
andiroba oil from the brazilian amazon |
topic | Mutagenesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910557/ https://www.ncbi.nlm.nih.gov/pubmed/27192128 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0098 |
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