Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS

The identification of activation pathways linked to antitumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy. We have recently reported that dacarbazine (DTIC) injected one day before peptide-vaccination plus IFN-α improves the antitumor lyt...

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Detalles Bibliográficos
Autores principales: Franzese, Ornella, Palermo, Belinda, Di Donna, Cosmo, Sperduti, Isabella, Ferraresi, Virginia, Stabile, Helena, Gismondi, Angela, Santoni, Angela, Nisticò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910730/
https://www.ncbi.nlm.nih.gov/pubmed/27467927
http://dx.doi.org/10.1080/2162402X.2015.1114203

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