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Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression

We have previously described a mouse model of human posterior polymorphous corneal dystrophy (PPCD) and localized the causative mutation to a 6.2 Mbp region of chromosome 2, termed Ppcd1. We now show that the gene rearrangement linked to mouse Ppcd1 is a 3.9 Mbp chromosomal inversion flanked by 81 K...

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Detalles Bibliográficos
Autores principales:	Shen, Anna L., Moran, Susan A., Glover, Edward A., Drinkwater, Norman R., Swearingen, Rebecca E., Teixeira, Leandro B., Bradfield, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910986/ https://www.ncbi.nlm.nih.gov/pubmed/27310661 http://dx.doi.org/10.1371/journal.pone.0157577

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