Cargando…

Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study

OBJECTIVE: Febrile neutropenia is common in children undergoing chemotherapy for the treatment of malignancies. In the majority of cases, the cause of the fever is unknown. Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains un...

Descripción completa

Detalles Bibliográficos
Autores principales: Söderman, Martina, Rhedin, Samuel, Tolfvenstam, Thomas, Rotzén-Östlund, Maria, Albert, Jan, Broliden, Kristina, Lindblom, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911076/
https://www.ncbi.nlm.nih.gov/pubmed/27309354
http://dx.doi.org/10.1371/journal.pone.0157398
_version_ 1782438080681082880
author Söderman, Martina
Rhedin, Samuel
Tolfvenstam, Thomas
Rotzén-Östlund, Maria
Albert, Jan
Broliden, Kristina
Lindblom, Anna
author_facet Söderman, Martina
Rhedin, Samuel
Tolfvenstam, Thomas
Rotzén-Östlund, Maria
Albert, Jan
Broliden, Kristina
Lindblom, Anna
author_sort Söderman, Martina
collection PubMed
description OBJECTIVE: Febrile neutropenia is common in children undergoing chemotherapy for the treatment of malignancies. In the majority of cases, the cause of the fever is unknown. Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study. STUDY DESIGN: Nasopharyngeal aspirates were collected during 87 episodes of febrile neutropenia in children age 0–18 years, being treated at a children’s oncology unit between January 2013 and June 2014. Real-time polymerase chain reaction was used to determine the presence of 16 respiratory viruses. Follow-up samples were collected from children who tested positive for one or more respiratory viruses. Rhinoviruses were genotyped by VP4/VP2 sequencing. Fisher’s exact test and Mann-Whitney U test were used for group comparisons. RESULTS: At least one respiratory virus was detected in samples from 39 of 87 episodes of febrile neutropenia (45%), with rhinoviruses the most frequently detected. Follow-up samples were collected after a median of 28 days (range, 9–74 days) in 32 of the 39 virus-positive episodes. The respiratory viral infection had resolved in 25 episodes (78%). The same virus was detected at follow-up in one coronavirus and six rhinovirus episodes. Genotyping revealed a different rhinovirus species in two of the six rhinovirus infections. CONCLUSION: The frequency of respiratory viral infections in this group of patients suggests an etiologic role in febrile neutropenia. However, these findings must be confirmed in larger patient cohorts.
format Online
Article
Text
id pubmed-4911076
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-49110762016-07-06 Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study Söderman, Martina Rhedin, Samuel Tolfvenstam, Thomas Rotzén-Östlund, Maria Albert, Jan Broliden, Kristina Lindblom, Anna PLoS One Research Article OBJECTIVE: Febrile neutropenia is common in children undergoing chemotherapy for the treatment of malignancies. In the majority of cases, the cause of the fever is unknown. Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study. STUDY DESIGN: Nasopharyngeal aspirates were collected during 87 episodes of febrile neutropenia in children age 0–18 years, being treated at a children’s oncology unit between January 2013 and June 2014. Real-time polymerase chain reaction was used to determine the presence of 16 respiratory viruses. Follow-up samples were collected from children who tested positive for one or more respiratory viruses. Rhinoviruses were genotyped by VP4/VP2 sequencing. Fisher’s exact test and Mann-Whitney U test were used for group comparisons. RESULTS: At least one respiratory virus was detected in samples from 39 of 87 episodes of febrile neutropenia (45%), with rhinoviruses the most frequently detected. Follow-up samples were collected after a median of 28 days (range, 9–74 days) in 32 of the 39 virus-positive episodes. The respiratory viral infection had resolved in 25 episodes (78%). The same virus was detected at follow-up in one coronavirus and six rhinovirus episodes. Genotyping revealed a different rhinovirus species in two of the six rhinovirus infections. CONCLUSION: The frequency of respiratory viral infections in this group of patients suggests an etiologic role in febrile neutropenia. However, these findings must be confirmed in larger patient cohorts. Public Library of Science 2016-06-16 /pmc/articles/PMC4911076/ /pubmed/27309354 http://dx.doi.org/10.1371/journal.pone.0157398 Text en © 2016 Söderman et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Söderman, Martina
Rhedin, Samuel
Tolfvenstam, Thomas
Rotzén-Östlund, Maria
Albert, Jan
Broliden, Kristina
Lindblom, Anna
Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title_full Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title_fullStr Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title_full_unstemmed Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title_short Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
title_sort frequent respiratory viral infections in children with febrile neutropenia - a prospective follow-up study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911076/
https://www.ncbi.nlm.nih.gov/pubmed/27309354
http://dx.doi.org/10.1371/journal.pone.0157398
work_keys_str_mv AT sodermanmartina frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT rhedinsamuel frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT tolfvenstamthomas frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT rotzenostlundmaria frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT albertjan frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT brolidenkristina frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy
AT lindblomanna frequentrespiratoryviralinfectionsinchildrenwithfebrileneutropeniaaprospectivefollowupstudy