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Sensory experience modifies feature map relationships in visual cortex
The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferret...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911216/ https://www.ncbi.nlm.nih.gov/pubmed/27310531 http://dx.doi.org/10.7554/eLife.13911 |
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author | Cloherty, Shaun L Hughes, Nicholas J Hietanen, Markus A Bhagavatula, Partha S Goodhill, Geoffrey J Ibbotson, Michael R |
author_facet | Cloherty, Shaun L Hughes, Nicholas J Hietanen, Markus A Bhagavatula, Partha S Goodhill, Geoffrey J Ibbotson, Michael R |
author_sort | Cloherty, Shaun L |
collection | PubMed |
description | The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by altered visual input. However, the spatial relationship between OP and OD maps has appeared immutable. Using a computational model we predicted that biasing the visual input to orthogonal orientation in the two eyes should cause a shift of OP pinwheels towards the border of OD columns. We then confirmed this prediction by rearing cats wearing orthogonally oriented cylindrical lenses over each eye. Thus, the spatial relationship between OP and OD maps can be modified by visual experience, revealing a previously unknown degree of brain plasticity in response to sensory input. DOI: http://dx.doi.org/10.7554/eLife.13911.001 |
format | Online Article Text |
id | pubmed-4911216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49112162016-06-20 Sensory experience modifies feature map relationships in visual cortex Cloherty, Shaun L Hughes, Nicholas J Hietanen, Markus A Bhagavatula, Partha S Goodhill, Geoffrey J Ibbotson, Michael R eLife Neuroscience The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by altered visual input. However, the spatial relationship between OP and OD maps has appeared immutable. Using a computational model we predicted that biasing the visual input to orthogonal orientation in the two eyes should cause a shift of OP pinwheels towards the border of OD columns. We then confirmed this prediction by rearing cats wearing orthogonally oriented cylindrical lenses over each eye. Thus, the spatial relationship between OP and OD maps can be modified by visual experience, revealing a previously unknown degree of brain plasticity in response to sensory input. DOI: http://dx.doi.org/10.7554/eLife.13911.001 eLife Sciences Publications, Ltd 2016-06-16 /pmc/articles/PMC4911216/ /pubmed/27310531 http://dx.doi.org/10.7554/eLife.13911 Text en © 2016, Cloherty et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Cloherty, Shaun L Hughes, Nicholas J Hietanen, Markus A Bhagavatula, Partha S Goodhill, Geoffrey J Ibbotson, Michael R Sensory experience modifies feature map relationships in visual cortex |
title | Sensory experience modifies feature map relationships in visual cortex |
title_full | Sensory experience modifies feature map relationships in visual cortex |
title_fullStr | Sensory experience modifies feature map relationships in visual cortex |
title_full_unstemmed | Sensory experience modifies feature map relationships in visual cortex |
title_short | Sensory experience modifies feature map relationships in visual cortex |
title_sort | sensory experience modifies feature map relationships in visual cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911216/ https://www.ncbi.nlm.nih.gov/pubmed/27310531 http://dx.doi.org/10.7554/eLife.13911 |
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