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Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report

Cytochrome P450 inhibition through fruit supplement interactions often results in increased serum levels of calcineurin inhibitors, including tacrolimus. Cranberry extract is a supplement often used for the prevention of recurrent urinary tract infections (UTIs), which are common in renal allograft...

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Detalles Bibliográficos
Autores principales: Dave, Atman A, Samuel, Jones
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911337/
https://www.ncbi.nlm.nih.gov/pubmed/27335715
http://dx.doi.org/10.7759/cureus.610
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author Dave, Atman A
Samuel, Jones
author_facet Dave, Atman A
Samuel, Jones
author_sort Dave, Atman A
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description Cytochrome P450 inhibition through fruit supplement interactions often results in increased serum levels of calcineurin inhibitors, including tacrolimus. Cranberry extract is a supplement often used for the prevention of recurrent urinary tract infections (UTIs), which are common in renal allograft recipients. To our knowledge, a decrease in serum levels of tacrolimus as a result of cranberry extract interaction is unreported. A 40-year-old renal transplant patient taking cranberry extract capsules for her recurrent cystitis presented asymptomatically with low serum levels of tacrolimus. Dose increase had little effect on the level, and cessation of the cranberry extract returned levels to desired range. Cranberry extracts are an adjunctive therapy used in the management of recurrent UTIs. Tacrolimus, an immunosuppressive agent, is metabolized intestinally by isoenzymes of the P450 cytochrome. Cranberry extracts may alter this metabolism and lead to sub-therapeutic serum levels of tacrolimus. This interaction is heretofore unreported. Cranberry extracts should be carefully monitored in allograft recipients due to interactions with serum tacrolimus levels.
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spelling pubmed-49113372016-06-22 Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report Dave, Atman A Samuel, Jones Cureus Nephrology Cytochrome P450 inhibition through fruit supplement interactions often results in increased serum levels of calcineurin inhibitors, including tacrolimus. Cranberry extract is a supplement often used for the prevention of recurrent urinary tract infections (UTIs), which are common in renal allograft recipients. To our knowledge, a decrease in serum levels of tacrolimus as a result of cranberry extract interaction is unreported. A 40-year-old renal transplant patient taking cranberry extract capsules for her recurrent cystitis presented asymptomatically with low serum levels of tacrolimus. Dose increase had little effect on the level, and cessation of the cranberry extract returned levels to desired range. Cranberry extracts are an adjunctive therapy used in the management of recurrent UTIs. Tacrolimus, an immunosuppressive agent, is metabolized intestinally by isoenzymes of the P450 cytochrome. Cranberry extracts may alter this metabolism and lead to sub-therapeutic serum levels of tacrolimus. This interaction is heretofore unreported. Cranberry extracts should be carefully monitored in allograft recipients due to interactions with serum tacrolimus levels. Cureus 2016-05-16 /pmc/articles/PMC4911337/ /pubmed/27335715 http://dx.doi.org/10.7759/cureus.610 Text en Copyright © 2016, Dave et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Nephrology
Dave, Atman A
Samuel, Jones
Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title_full Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title_fullStr Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title_full_unstemmed Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title_short Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report
title_sort suspected interaction of cranberry juice extracts and tacrolimus serum levels: a case report
topic Nephrology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911337/
https://www.ncbi.nlm.nih.gov/pubmed/27335715
http://dx.doi.org/10.7759/cureus.610
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