Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle...

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Detalles Bibliográficos
Autores principales: Rocchi, Anna, Milioto, Carmelo, Parodi, Sara, Armirotti, Andrea, Borgia, Doriana, Pellegrini, Matteo, Urciuolo, Anna, Molon, Sibilla, Morbidoni, Valeria, Marabita, Manuela, Romanello, Vanina, Gatto, Pamela, Blaauw, Bert, Bonaldo, Paolo, Sambataro, Fabio, Robins, Diane M., Lieberman, Andrew P., Sorarù, Gianni, Vergani, Lodovica, Sandri, Marco, Pennuto, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911374/
https://www.ncbi.nlm.nih.gov/pubmed/26971100
http://dx.doi.org/10.1007/s00401-016-1550-4

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