Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen

In the pathogenesis of central nervous system (CNS) demyelinating disorders, antigen-specific B cells are implicated to act as potent antigen-presenting cells (APC), eliciting waves of inflammatory CNS infiltration. Here, we provide the first evidence that CNS-reactive antibodies (Ab) are similarly...

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Detalles Bibliográficos
Autores principales: Kinzel, Silke, Lehmann-Horn, Klaus, Torke, Sebastian, Häusler, Darius, Winkler, Anne, Stadelmann, Christine, Payne, Natalie, Feldmann, Linda, Saiz, Albert, Reindl, Markus, Lalive, Patrice H., Bernard, Claude C., Brück, Wolfgang, Weber, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911382/
https://www.ncbi.nlm.nih.gov/pubmed/27022743
http://dx.doi.org/10.1007/s00401-016-1559-8

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