Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice

De novo ASXL1 mutations are found in patients with Bohring-Opitz syndrome, a disease with severe developmental defects and early childhood mortality. The underlying pathologic mechanisms remain largely unknown. Using Asxl1-targeted murine models, we found that Asxl1 global loss as well as conditiona...

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Detalles Bibliográficos
Autores principales: Zhang, Peng, Xing, Caihong, Rhodes, Steven D., He, Yongzheng, Deng, Kai, Li, Zhaomin, He, Fuhong, Zhu, Caiying, Nguyen, Lihn, Zhou, Yuan, Chen, Shi, Mohammad, Khalid S., Guise, Theresa A., Abdel-Wahab, Omar, Xu, Mingjiang, Wang, Qian-Fei, Yang, Feng-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911496/
https://www.ncbi.nlm.nih.gov/pubmed/27237378
http://dx.doi.org/10.1016/j.stemcr.2016.04.013

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