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Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88

Toll-like receptor 4 (TLR4) plays a central role in host responses to bacterial infection, but the precise mechanism(s) by which its downstream signaling components coordinate the bone marrow response to sepsis is poorly understood. Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we...

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Detalles Bibliográficos
Autores principales:	Zhang, Huajia, Rodriguez, Sonia, Wang, Lin, Wang, Soujuan, Serezani, Henrique, Kapur, Reuben, Cardoso, Angelo A., Carlesso, Nadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911503/ https://www.ncbi.nlm.nih.gov/pubmed/27264973 http://dx.doi.org/10.1016/j.stemcr.2016.05.002

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