Cargando…

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88

Toll-like receptor 4 (TLR4) plays a central role in host responses to bacterial infection, but the precise mechanism(s) by which its downstream signaling components coordinate the bone marrow response to sepsis is poorly understood. Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Huajia, Rodriguez, Sonia, Wang, Lin, Wang, Soujuan, Serezani, Henrique, Kapur, Reuben, Cardoso, Angelo A., Carlesso, Nadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911503/ https://www.ncbi.nlm.nih.gov/pubmed/27264973 http://dx.doi.org/10.1016/j.stemcr.2016.05.002

Ejemplares similares

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Beyond MyD88 and TRIF Pathways in Toll-Like Receptor Signaling
por: Piras, Vincent, et al.
Publicado: (2014)

MyD88 and TRIF mediate divergent inflammatory and regenerative responses to skeletal muscle ischemia
por: Sachdev, Ulka, et al.
Publicado: (2014)

Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice
por: Heuss, Neal D, et al.
Publicado: (2014)

Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer
por: Zambirinis, Constantinos P., et al.
Publicado: (2013)

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes
por: Androulidaki, Ariadne, et al.
Publicado: (2018)

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
por: Pereira, Milton, et al.
Publicado: (2022)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, Diacyl Lipopeptide, and IL-1α
por: Sato, Nobuaki, et al.
Publicado: (2004)

Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways
por: Pang, Zheng, et al.
Publicado: (2018)

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
por: Semple, Fiona, et al.
Publicado: (2011)

Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection
por: Kirsebom, Freja C. M., et al.
Publicado: (2019)

Mechanism of focal cerebral ischemic tolerance in rats with ischemic preconditioning involves MyD88- and TRIF-dependent pathways
por: LI, HAN, et al.
Publicado: (2013)

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
por: Lin, Sen, et al.
Publicado: (2012)

Immunohistochemical Analysis of Toll-Like Receptors, MyD88, and TRIF in Human Papillary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma
por: Nihon-Yanagi, Yasuhiro, et al.
Publicado: (2021)

Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish
por: Srivastava, Nidhi, et al.
Publicado: (2017)

MyD88 Is Not Required for Muscle Injury-Induced Endochondral Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva
por: Lyu, Huili, et al.
Publicado: (2021)

Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop
por: Liang, Shuang, et al.
Publicado: (2019)

Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis
por: van Lieshout, Miriam H. P., et al.
Publicado: (2014)

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer
por: Chuffa, Luiz Gustavo A, et al.
Publicado: (2015)

Simvastatin improves cerebrovascular injury caused by ischemia-reperfusion through NF-κB-mediated apoptosis via MyD88/TRIF signaling
por: Chen, Zhiying, et al.
Publicado: (2018)

Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro
por: Kobayashi, Nobuhide, et al.
Publicado: (2022)

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways
por: Díaz-Dinamarca, Diego A., et al.
Publicado: (2023)

MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line
por: Uh, Andy, et al.
Publicado: (2009)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice
por: Zhu, Yingli, et al.
Publicado: (2016)

Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway
por: Hu, Yue, et al.
Publicado: (2016)

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection
por: Karmakar, Joyshree, et al.
Publicado: (2021)

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
por: Munshi, Manit, et al.
Publicado: (2020)

Downregulation of Paralemmin-3 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating Inflammatory Response and Inhibiting Formation of TLR4/MyD88 and TLR4/TRIF Complexes
por: Chen, Xuxin, et al.
Publicado: (2017)

Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils
por: Zhang, Huajia, et al.
Publicado: (2022)

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis
por: Pan, Xiao, et al.
Publicado: (2022)

MyD88 Is a Critical Regulator of Hematopoietic Cell-Mediated Neuroprotection Seen after Stroke
por: Downes, Catherine E., et al.
Publicado: (2013)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E(2)-Mediated M2 Generation
por: Wang, Zhuo, et al.
Publicado: (2015)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy
por: Brenet, Fabienne, et al.
Publicado: (2013)

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
por: George, Julie, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_s8navjmpufe5gf9tc5g3msl547