Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report

A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant stain...

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Detalles Bibliográficos
Autores principales: Kubota, Keiichi, Hoshino, Junichi, Ueno, Toshiharu, Mise, Koki, Hazue, Ryo, Sekine, Akinari, Yabuuchi, Junko, Yamanouchi, Masayuki, Suwabe, Tatsuya, Kikuchi, Koichi, Sumida, Keiichi, Hayami, Noriko, Sawa, Naoki, Takaichi, Kenmei, Fujii, Takeshi, Ohashi, Kenichi, Akiyama, Shinichi, Maruyama, Shoichi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Published online: May, 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911527/
https://www.ncbi.nlm.nih.gov/pubmed/27390744
http://dx.doi.org/10.1159/000446019
Descripción
Sumario:A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant staining. This patient did not have any underlying disease such as infection with hepatitis B or C virus or malignancy, and anti-phospholipase A2 receptor (PLA2R) antibody was detected in the serum. Accordingly, idiopathic MGN was diagnosed. Corticosteroid therapy was avoided, but hemodialysis was required to treat generalized edema. The patient is currently doing well. This is the oldest reported case of idiopathic MGN with positivity for anti-PLA2R antibody.

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