Cargando…
Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report
A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant stain...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
S. Karger AG
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911527/ https://www.ncbi.nlm.nih.gov/pubmed/27390744 http://dx.doi.org/10.1159/000446019 |
| _version_ | 1782438143349227520 |
|---|---|
| author | Kubota, Keiichi Hoshino, Junichi Ueno, Toshiharu Mise, Koki Hazue, Ryo Sekine, Akinari Yabuuchi, Junko Yamanouchi, Masayuki Suwabe, Tatsuya Kikuchi, Koichi Sumida, Keiichi Hayami, Noriko Sawa, Naoki Takaichi, Kenmei Fujii, Takeshi Ohashi, Kenichi Akiyama, Shinichi Maruyama, Shoichi Ubara, Yoshifumi |
| author_facet | Kubota, Keiichi Hoshino, Junichi Ueno, Toshiharu Mise, Koki Hazue, Ryo Sekine, Akinari Yabuuchi, Junko Yamanouchi, Masayuki Suwabe, Tatsuya Kikuchi, Koichi Sumida, Keiichi Hayami, Noriko Sawa, Naoki Takaichi, Kenmei Fujii, Takeshi Ohashi, Kenichi Akiyama, Shinichi Maruyama, Shoichi Ubara, Yoshifumi |
| author_sort | Kubota, Keiichi |
| collection | PubMed |
| description | A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant staining. This patient did not have any underlying disease such as infection with hepatitis B or C virus or malignancy, and anti-phospholipase A2 receptor (PLA2R) antibody was detected in the serum. Accordingly, idiopathic MGN was diagnosed. Corticosteroid therapy was avoided, but hemodialysis was required to treat generalized edema. The patient is currently doing well. This is the oldest reported case of idiopathic MGN with positivity for anti-PLA2R antibody. |
| format | Online Article Text |
| id | pubmed-4911527 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | S. Karger AG |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49115272016-07-07 Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report Kubota, Keiichi Hoshino, Junichi Ueno, Toshiharu Mise, Koki Hazue, Ryo Sekine, Akinari Yabuuchi, Junko Yamanouchi, Masayuki Suwabe, Tatsuya Kikuchi, Koichi Sumida, Keiichi Hayami, Noriko Sawa, Naoki Takaichi, Kenmei Fujii, Takeshi Ohashi, Kenichi Akiyama, Shinichi Maruyama, Shoichi Ubara, Yoshifumi Case Rep Nephrol Dial Published online: May, 2016 A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant staining. This patient did not have any underlying disease such as infection with hepatitis B or C virus or malignancy, and anti-phospholipase A2 receptor (PLA2R) antibody was detected in the serum. Accordingly, idiopathic MGN was diagnosed. Corticosteroid therapy was avoided, but hemodialysis was required to treat generalized edema. The patient is currently doing well. This is the oldest reported case of idiopathic MGN with positivity for anti-PLA2R antibody. S. Karger AG 2016-05-24 /pmc/articles/PMC4911527/ /pubmed/27390744 http://dx.doi.org/10.1159/000446019 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
| spellingShingle | Published online: May, 2016 Kubota, Keiichi Hoshino, Junichi Ueno, Toshiharu Mise, Koki Hazue, Ryo Sekine, Akinari Yabuuchi, Junko Yamanouchi, Masayuki Suwabe, Tatsuya Kikuchi, Koichi Sumida, Keiichi Hayami, Noriko Sawa, Naoki Takaichi, Kenmei Fujii, Takeshi Ohashi, Kenichi Akiyama, Shinichi Maruyama, Shoichi Ubara, Yoshifumi Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title | Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title_full | Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title_fullStr | Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title_full_unstemmed | Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title_short | Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report |
| title_sort | phospholipase a2 receptor-positive idiopathic membranous glomerulonephritis with onset at 95 years: case report |
| topic | Published online: May, 2016 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911527/ https://www.ncbi.nlm.nih.gov/pubmed/27390744 http://dx.doi.org/10.1159/000446019 |
| work_keys_str_mv | AT kubotakeiichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT hoshinojunichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT uenotoshiharu phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT misekoki phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT hazueryo phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT sekineakinari phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT yabuuchijunko phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT yamanouchimasayuki phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT suwabetatsuya phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT kikuchikoichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT sumidakeiichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT hayaminoriko phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT sawanaoki phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT takaichikenmei phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT fujiitakeshi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT ohashikenichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT akiyamashinichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT maruyamashoichi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport AT ubarayoshifumi phospholipasea2receptorpositiveidiopathicmembranousglomerulonephritiswithonsetat95yearscasereport |