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Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction

We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on COX2/PGE2 and filaggrin. PMs induced increase...

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Detalles Bibliográficos
Autores principales:	Lee, Chiang-Wen, Lin, Zih-Chan, Hu, Stephen Chu-Sung, Chiang, Yao-Chang, Hsu, Lee-Fen, Lin, Yu-Ching, Lee, I-Ta, Tsai, Ming-Horng, Fang, Jia-You
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911555/ https://www.ncbi.nlm.nih.gov/pubmed/27313009 http://dx.doi.org/10.1038/srep27995

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