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Procalcitonin as diagnostic marker of infection in solid tumors patients with fever
In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911581/ https://www.ncbi.nlm.nih.gov/pubmed/27312877 http://dx.doi.org/10.1038/srep28090 |
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author | Vincenzi, B. Fioroni, I. Pantano, F. Angeletti, S. Dicuonzo, G. Zoccoli, A. Santini, D. Tonini, G. |
author_facet | Vincenzi, B. Fioroni, I. Pantano, F. Angeletti, S. Dicuonzo, G. Zoccoli, A. Santini, D. Tonini, G. |
author_sort | Vincenzi, B. |
collection | PubMed |
description | In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective study enrolled 431 patients. All of them performed hemoculture (HE) and basal PCT assessment (reference laboratory cut-off: ≤0.5 or >0.5 ng/dL) before starting antibiotic therapy. Gram positive (G+), negative (G−) or Fungi infection were detected. A statistically significant difference in PCT levels between patients with positive and negative HE was observed (P < 0.0001). Moreover comparing PCT values in patients with positive and negative HE, we obtain in the positive HE subpopulation an AUC of 0.7 and a cut-off of 1.52 ng/dL reached high sensitivity (61.6%) and specificity (70.1%). Using this last cut-off, instead of the normal reference value, we achieve a risk reduction to overestimate an infection status of 23.4%. We support the clinic usefulness of serum PCT dosage in febrile advanced solid tumor patients. A PCT cut-off of 1.52 ng/dL could be helpful in the management of the antibiotic therapy preventing delays of oncologic treatments. |
format | Online Article Text |
id | pubmed-4911581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49115812016-06-17 Procalcitonin as diagnostic marker of infection in solid tumors patients with fever Vincenzi, B. Fioroni, I. Pantano, F. Angeletti, S. Dicuonzo, G. Zoccoli, A. Santini, D. Tonini, G. Sci Rep Article In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective study enrolled 431 patients. All of them performed hemoculture (HE) and basal PCT assessment (reference laboratory cut-off: ≤0.5 or >0.5 ng/dL) before starting antibiotic therapy. Gram positive (G+), negative (G−) or Fungi infection were detected. A statistically significant difference in PCT levels between patients with positive and negative HE was observed (P < 0.0001). Moreover comparing PCT values in patients with positive and negative HE, we obtain in the positive HE subpopulation an AUC of 0.7 and a cut-off of 1.52 ng/dL reached high sensitivity (61.6%) and specificity (70.1%). Using this last cut-off, instead of the normal reference value, we achieve a risk reduction to overestimate an infection status of 23.4%. We support the clinic usefulness of serum PCT dosage in febrile advanced solid tumor patients. A PCT cut-off of 1.52 ng/dL could be helpful in the management of the antibiotic therapy preventing delays of oncologic treatments. Nature Publishing Group 2016-06-17 /pmc/articles/PMC4911581/ /pubmed/27312877 http://dx.doi.org/10.1038/srep28090 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Vincenzi, B. Fioroni, I. Pantano, F. Angeletti, S. Dicuonzo, G. Zoccoli, A. Santini, D. Tonini, G. Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title | Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title_full | Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title_fullStr | Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title_full_unstemmed | Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title_short | Procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
title_sort | procalcitonin as diagnostic marker of infection in solid tumors patients with fever |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911581/ https://www.ncbi.nlm.nih.gov/pubmed/27312877 http://dx.doi.org/10.1038/srep28090 |
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