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FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests

Breath volatile organic compound (VOC) analysis can open a non-invasive window onto pathological and metabolic processes in the body. Decades of clinical breath-gas analysis have revealed that changes in exhaled VOC concentrations are important rather than disease specific biomarkers. As physiologic...

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Autores principales: Sukul, Pritam, Schubert, Jochen K., Oertel, Peter, Kamysek, Svend, Taunk, Khushman, Trefz, Phillip, Miekisch, Wolfram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911606/
https://www.ncbi.nlm.nih.gov/pubmed/27311826
http://dx.doi.org/10.1038/srep28029
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author Sukul, Pritam
Schubert, Jochen K.
Oertel, Peter
Kamysek, Svend
Taunk, Khushman
Trefz, Phillip
Miekisch, Wolfram
author_facet Sukul, Pritam
Schubert, Jochen K.
Oertel, Peter
Kamysek, Svend
Taunk, Khushman
Trefz, Phillip
Miekisch, Wolfram
author_sort Sukul, Pritam
collection PubMed
description Breath volatile organic compound (VOC) analysis can open a non-invasive window onto pathological and metabolic processes in the body. Decades of clinical breath-gas analysis have revealed that changes in exhaled VOC concentrations are important rather than disease specific biomarkers. As physiological parameters, such as respiratory rate or cardiac output, have profound effects on exhaled VOCs, here we investigated VOC exhalation under respiratory manoeuvres. Breath VOCs were monitored by means of real-time mass-spectrometry during conventional FEV manoeuvres in 50 healthy humans. Simultaneously, we measured respiratory and hemodynamic parameters noninvasively. Tidal volume and minute ventilation increased by 292 and 171% during the manoeuvre. FEV manoeuvre induced substance specific changes in VOC concentrations. pET-CO(2) and alveolar isoprene increased by 6 and 21% during maximum exhalation. Then they decreased by 18 and 37% at forced expiration mirroring cardiac output. Acetone concentrations rose by 4.5% despite increasing minute ventilation. Blood-borne furan and dimethyl-sulphide mimicked isoprene profile. Exogenous acetonitrile, sulphides, and most aliphatic and aromatic VOCs changed minimally. Reliable breath tests must avoid forced breathing. As isoprene exhalations mirrored FEV performances, endogenous VOCs might assure quality of lung function tests. Analysis of exhaled VOC concentrations can provide additional information on physiology of respiration and gas exchange.
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spelling pubmed-49116062016-06-17 FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests Sukul, Pritam Schubert, Jochen K. Oertel, Peter Kamysek, Svend Taunk, Khushman Trefz, Phillip Miekisch, Wolfram Sci Rep Article Breath volatile organic compound (VOC) analysis can open a non-invasive window onto pathological and metabolic processes in the body. Decades of clinical breath-gas analysis have revealed that changes in exhaled VOC concentrations are important rather than disease specific biomarkers. As physiological parameters, such as respiratory rate or cardiac output, have profound effects on exhaled VOCs, here we investigated VOC exhalation under respiratory manoeuvres. Breath VOCs were monitored by means of real-time mass-spectrometry during conventional FEV manoeuvres in 50 healthy humans. Simultaneously, we measured respiratory and hemodynamic parameters noninvasively. Tidal volume and minute ventilation increased by 292 and 171% during the manoeuvre. FEV manoeuvre induced substance specific changes in VOC concentrations. pET-CO(2) and alveolar isoprene increased by 6 and 21% during maximum exhalation. Then they decreased by 18 and 37% at forced expiration mirroring cardiac output. Acetone concentrations rose by 4.5% despite increasing minute ventilation. Blood-borne furan and dimethyl-sulphide mimicked isoprene profile. Exogenous acetonitrile, sulphides, and most aliphatic and aromatic VOCs changed minimally. Reliable breath tests must avoid forced breathing. As isoprene exhalations mirrored FEV performances, endogenous VOCs might assure quality of lung function tests. Analysis of exhaled VOC concentrations can provide additional information on physiology of respiration and gas exchange. Nature Publishing Group 2016-06-17 /pmc/articles/PMC4911606/ /pubmed/27311826 http://dx.doi.org/10.1038/srep28029 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sukul, Pritam
Schubert, Jochen K.
Oertel, Peter
Kamysek, Svend
Taunk, Khushman
Trefz, Phillip
Miekisch, Wolfram
FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title_full FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title_fullStr FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title_full_unstemmed FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title_short FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
title_sort fev manoeuvre induced changes in breath voc compositions: an unconventional view on lung function tests
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911606/
https://www.ncbi.nlm.nih.gov/pubmed/27311826
http://dx.doi.org/10.1038/srep28029
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