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Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies

Background: It has been reported that anatomical resection of the liver may be preferred for primary hepatocellular carcinoma (HCC), and is at least recommended for systematic removal of a segment confined by tumor-bearing portal tributaries. However, nonanatomical resection (NAR) is often selected...

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Autores principales: Sakoda, Masahiko, Ueno, Shinichi, Iino, Satoshi, Hiwatashi, Kiyokazu, Minami, Koji, Kawasaki, Yota, Kurahara, Hiroshi, Mataki, Yuko, Maemura, Kosei, Shinchi, Hiroyuki, Natsugoe, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911868/
https://www.ncbi.nlm.nih.gov/pubmed/27326244
http://dx.doi.org/10.7150/jca.15174
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author Sakoda, Masahiko
Ueno, Shinichi
Iino, Satoshi
Hiwatashi, Kiyokazu
Minami, Koji
Kawasaki, Yota
Kurahara, Hiroshi
Mataki, Yuko
Maemura, Kosei
Shinchi, Hiroyuki
Natsugoe, Shoji
author_facet Sakoda, Masahiko
Ueno, Shinichi
Iino, Satoshi
Hiwatashi, Kiyokazu
Minami, Koji
Kawasaki, Yota
Kurahara, Hiroshi
Mataki, Yuko
Maemura, Kosei
Shinchi, Hiroyuki
Natsugoe, Shoji
author_sort Sakoda, Masahiko
collection PubMed
description Background: It has been reported that anatomical resection of the liver may be preferred for primary hepatocellular carcinoma (HCC), and is at least recommended for systematic removal of a segment confined by tumor-bearing portal tributaries. However, nonanatomical resection (NAR) is often selected because of the patient's background, impairment of liver function, and tumor factors. The aims of the present study were to retrospectively compare the recurrence-free survival (RFS) rates for cases of partial resection (PR) and for small anatomical resection (SAR), which is regarded as NAR for primary HCC with impaired liver function. Patients and Methods: So-called NAR was performed for a primary and solitary (≤ 5cm) HCC in 47 patients; the patients were classified into PR (n=25) and SAR (n=22) groups. Clinicopathological factors, survival data, and recurrence patterns were compared between groups. Results: There were no significant differences in the preoperative characteristics between the two groups. Operative time was significantly longer in the SAR group than in the PR group. There was no significant difference in the postoperative morbidity and tumor pathological characteristics between the two groups. The RFS of the SAR group was significantly better than those of the PR group. Although there was no significant difference in the pattern of recurrence between the two groups, the rate of intrahepatic recurrence in the same segment as the initial tumor tended to be higher in the PR group than in the SAR group. Multivariate analysis revealed that only the PR operative procedure was significant independent risk factor for poorer RFS. Conclusion: Compared with PR, SAR effectively improves the rate of RFS after surgery for a primary and solitary HCC with impaired liver function.
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spelling pubmed-49118682016-06-20 Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies Sakoda, Masahiko Ueno, Shinichi Iino, Satoshi Hiwatashi, Kiyokazu Minami, Koji Kawasaki, Yota Kurahara, Hiroshi Mataki, Yuko Maemura, Kosei Shinchi, Hiroyuki Natsugoe, Shoji J Cancer Research Paper Background: It has been reported that anatomical resection of the liver may be preferred for primary hepatocellular carcinoma (HCC), and is at least recommended for systematic removal of a segment confined by tumor-bearing portal tributaries. However, nonanatomical resection (NAR) is often selected because of the patient's background, impairment of liver function, and tumor factors. The aims of the present study were to retrospectively compare the recurrence-free survival (RFS) rates for cases of partial resection (PR) and for small anatomical resection (SAR), which is regarded as NAR for primary HCC with impaired liver function. Patients and Methods: So-called NAR was performed for a primary and solitary (≤ 5cm) HCC in 47 patients; the patients were classified into PR (n=25) and SAR (n=22) groups. Clinicopathological factors, survival data, and recurrence patterns were compared between groups. Results: There were no significant differences in the preoperative characteristics between the two groups. Operative time was significantly longer in the SAR group than in the PR group. There was no significant difference in the postoperative morbidity and tumor pathological characteristics between the two groups. The RFS of the SAR group was significantly better than those of the PR group. Although there was no significant difference in the pattern of recurrence between the two groups, the rate of intrahepatic recurrence in the same segment as the initial tumor tended to be higher in the PR group than in the SAR group. Multivariate analysis revealed that only the PR operative procedure was significant independent risk factor for poorer RFS. Conclusion: Compared with PR, SAR effectively improves the rate of RFS after surgery for a primary and solitary HCC with impaired liver function. Ivyspring International Publisher 2016-05-25 /pmc/articles/PMC4911868/ /pubmed/27326244 http://dx.doi.org/10.7150/jca.15174 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Sakoda, Masahiko
Ueno, Shinichi
Iino, Satoshi
Hiwatashi, Kiyokazu
Minami, Koji
Kawasaki, Yota
Kurahara, Hiroshi
Mataki, Yuko
Maemura, Kosei
Shinchi, Hiroyuki
Natsugoe, Shoji
Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title_full Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title_fullStr Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title_full_unstemmed Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title_short Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
title_sort survival benefits of small anatomical resection of the liver for patients with hepatocellular carcinoma and impaired liver function, based on new-era imaging studies
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911868/
https://www.ncbi.nlm.nih.gov/pubmed/27326244
http://dx.doi.org/10.7150/jca.15174
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