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Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory

Introduction: The prevalence of cervical Human Papillomavirus (HPV) infection varies greatly worldwide and data regarding HPV prevalence and genotypes in China are limited. Methods: HPV testing results were retrospectively examined at KingMed Diagnostics, the largest independent pathology laboratory...

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Autores principales: Zeng, Zhengyu, Yang, Huaitao, Li, Zaibo, He, Xuekui, Griffith, Christopher C., Chen, Xiamen, Guo, Xiaolei, Zheng, Baowen, Wu, Shangwei, Zhao, Chengquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911869/
https://www.ncbi.nlm.nih.gov/pubmed/27326245
http://dx.doi.org/10.7150/jca.14971
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author Zeng, Zhengyu
Yang, Huaitao
Li, Zaibo
He, Xuekui
Griffith, Christopher C.
Chen, Xiamen
Guo, Xiaolei
Zheng, Baowen
Wu, Shangwei
Zhao, Chengquan
author_facet Zeng, Zhengyu
Yang, Huaitao
Li, Zaibo
He, Xuekui
Griffith, Christopher C.
Chen, Xiamen
Guo, Xiaolei
Zheng, Baowen
Wu, Shangwei
Zhao, Chengquan
author_sort Zeng, Zhengyu
collection PubMed
description Introduction: The prevalence of cervical Human Papillomavirus (HPV) infection varies greatly worldwide and data regarding HPV prevalence and genotypes in China are limited. Methods: HPV testing results were retrospectively examined at KingMed Diagnostics, the largest independent pathology laboratory in China, from January 2011 to June 2014. All testing was performed using the 26 HPV Genotyping Panel of Tellgenplex(TM) xMAP™ HPV DNA Test assay (TELLGEN, Shanghai, China). Overall prevalence, age-specific prevalence and genotype distributions were analyzed. Results: A total of 51,345 samples were tested and the overall HPV prevalence was 26%, with 21.12% positive for high risk (HR) HPV and 8.37% positive for low risk HPV. 80% of HPV positive cases were positive for a single HPV type. The three most common HR HPV types detected were HPV-52, -16, and -58, in descending order. HPV-18 was only the 6(th) most common type. When women were divided into three age groups: <30, 30-49, ≥50 years, HR HPV had the highest prevalence rate in women <30 years, and the lowest rate in women 30-49 years of age. The distribution of HR HPV genotypes also varied among these three age groups. Conclusions: To the best of our knowledge, this is largest routine clinical practice report of HPV prevalence and genotypes in a population of women having limited cervical cancer screening. HPV-52 was the most prevalent HR HPV type in this population of women followed by HPV-16 and HPV-58. The overall and age-specific prevalence and genotype distribution of HR HPV are different in this Chinese population compared to that reported from Western countries.
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spelling pubmed-49118692016-06-20 Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory Zeng, Zhengyu Yang, Huaitao Li, Zaibo He, Xuekui Griffith, Christopher C. Chen, Xiamen Guo, Xiaolei Zheng, Baowen Wu, Shangwei Zhao, Chengquan J Cancer Research Paper Introduction: The prevalence of cervical Human Papillomavirus (HPV) infection varies greatly worldwide and data regarding HPV prevalence and genotypes in China are limited. Methods: HPV testing results were retrospectively examined at KingMed Diagnostics, the largest independent pathology laboratory in China, from January 2011 to June 2014. All testing was performed using the 26 HPV Genotyping Panel of Tellgenplex(TM) xMAP™ HPV DNA Test assay (TELLGEN, Shanghai, China). Overall prevalence, age-specific prevalence and genotype distributions were analyzed. Results: A total of 51,345 samples were tested and the overall HPV prevalence was 26%, with 21.12% positive for high risk (HR) HPV and 8.37% positive for low risk HPV. 80% of HPV positive cases were positive for a single HPV type. The three most common HR HPV types detected were HPV-52, -16, and -58, in descending order. HPV-18 was only the 6(th) most common type. When women were divided into three age groups: <30, 30-49, ≥50 years, HR HPV had the highest prevalence rate in women <30 years, and the lowest rate in women 30-49 years of age. The distribution of HR HPV genotypes also varied among these three age groups. Conclusions: To the best of our knowledge, this is largest routine clinical practice report of HPV prevalence and genotypes in a population of women having limited cervical cancer screening. HPV-52 was the most prevalent HR HPV type in this population of women followed by HPV-16 and HPV-58. The overall and age-specific prevalence and genotype distribution of HR HPV are different in this Chinese population compared to that reported from Western countries. Ivyspring International Publisher 2016-05-25 /pmc/articles/PMC4911869/ /pubmed/27326245 http://dx.doi.org/10.7150/jca.14971 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Zeng, Zhengyu
Yang, Huaitao
Li, Zaibo
He, Xuekui
Griffith, Christopher C.
Chen, Xiamen
Guo, Xiaolei
Zheng, Baowen
Wu, Shangwei
Zhao, Chengquan
Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title_full Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title_fullStr Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title_full_unstemmed Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title_short Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
title_sort prevalence and genotype distribution of hpv infection in china: analysis of 51,345 hpv genotyping results from china's largest cap certified laboratory
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911869/
https://www.ncbi.nlm.nih.gov/pubmed/27326245
http://dx.doi.org/10.7150/jca.14971
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