Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis

Multiciliogenesis is essential for the function of different epithelia, and its failure results in brain defects, respiratory diseases, and infertility. In this issue of Genes & Development, Nemajerova and colleagues (pp. 1300–1312) reveal the p53 family member and p73 isoform TAp73 as a transcr...

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Detalles Bibliográficos
Autores principales: Napoli, Marco, Flores, Elsa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911924/
https://www.ncbi.nlm.nih.gov/pubmed/27298333
http://dx.doi.org/10.1101/gad.283663.116
Descripción
Sumario:Multiciliogenesis is essential for the function of different epithelia, and its failure results in brain defects, respiratory diseases, and infertility. In this issue of Genes & Development, Nemajerova and colleagues (pp. 1300–1312) reveal the p53 family member and p73 isoform TAp73 as a transcription factor dictating the differentiation of multiciliated cells. Their findings provide the long-awaited unifying explanation for the diverse phenotypes of the p73 knockout mice.

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