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LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncanonical glutamine pathway that is reliant on...

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Detalles Bibliográficos
Autores principales:	Xu, Pan, Oosterveer, Maaike H., Stein, Sokrates, Demagny, Hadrien, Ryu, Dongryeol, Moullan, Norman, Wang, Xu, Can, Emine, Zamboni, Nicola, Comment, Arnaud, Auwerx, Johan, Schoonjans, Kristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911925/ https://www.ncbi.nlm.nih.gov/pubmed/27298334 http://dx.doi.org/10.1101/gad.277483.116

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