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Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells

Acute myeloid leukemias (AMLs) with a rearrangement of the mixed-linage leukemia (MLL) gene are aggressive hematopoietic malignancies. Here, we explored the feasibility of using the H3K9- and H3K36-specific demethylases Jmjd2/Kdm4 as putative drug targets in MLL-AF9 translocated leukemia. Using Jmjd...

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Detalles Bibliográficos
Autores principales:	Agger, Karl, Miyagi, Satoru, Pedersen, Marianne Terndrup, Kooistra, Susanne M., Johansen, Jens Vilstrup, Helin, Kristian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911927/ https://www.ncbi.nlm.nih.gov/pubmed/27257215 http://dx.doi.org/10.1101/gad.280495.116

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