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Tau protein as a biomarker for asphyxia: A possible forensic tool?

Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNS markers for asphyxia. The cytoskeletal proteins seem to be attractive...

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Detalles Bibliográficos
Autores principales: Salama, Mohamed, Mohamed, Wael M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912031/
https://www.ncbi.nlm.nih.gov/pubmed/27354936
http://dx.doi.org/10.1016/j.atg.2016.03.001
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author Salama, Mohamed
Mohamed, Wael M.Y.
author_facet Salama, Mohamed
Mohamed, Wael M.Y.
author_sort Salama, Mohamed
collection PubMed
description Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNS markers for asphyxia. The cytoskeletal proteins seem to be attractive targets as they are vulnerable to hypoxia and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report we show the affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia. This may give new clues to asphyxial death investigations.
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spelling pubmed-49120312016-06-28 Tau protein as a biomarker for asphyxia: A possible forensic tool? Salama, Mohamed Mohamed, Wael M.Y. Appl Transl Genom Article Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNS markers for asphyxia. The cytoskeletal proteins seem to be attractive targets as they are vulnerable to hypoxia and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report we show the affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia. This may give new clues to asphyxial death investigations. Elsevier 2016-03-03 /pmc/articles/PMC4912031/ /pubmed/27354936 http://dx.doi.org/10.1016/j.atg.2016.03.001 Text en © 2016 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Salama, Mohamed
Mohamed, Wael M.Y.
Tau protein as a biomarker for asphyxia: A possible forensic tool?
title Tau protein as a biomarker for asphyxia: A possible forensic tool?
title_full Tau protein as a biomarker for asphyxia: A possible forensic tool?
title_fullStr Tau protein as a biomarker for asphyxia: A possible forensic tool?
title_full_unstemmed Tau protein as a biomarker for asphyxia: A possible forensic tool?
title_short Tau protein as a biomarker for asphyxia: A possible forensic tool?
title_sort tau protein as a biomarker for asphyxia: a possible forensic tool?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912031/
https://www.ncbi.nlm.nih.gov/pubmed/27354936
http://dx.doi.org/10.1016/j.atg.2016.03.001
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