Cargando…

Sumoylation Inhibits the Growth Suppressive Properties of Ikaros

The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Apostolov, Apostol, Litim-Mecheri, Isma, Oravecz, Attila, Goepp, Marie, Kirstetter, Peggy, Marchal, Patricia, Ittel, Antoine, Mauvieux, Laurent, Chan, Susan, Kastner, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912065/ https://www.ncbi.nlm.nih.gov/pubmed/27315244 http://dx.doi.org/10.1371/journal.pone.0157767

Ejemplares similares

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2
por: Oravecz, Attila, et al.
Publicado: (2015)

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development
por: Mastio, Jérôme, et al.
Publicado: (2018)

Correction: Sumoylation Inhibits the Growth Suppressive Properties of Ikaros
Publicado: (2016)

Ikaros antagonizes DNA binding by STAT5 in pre-B cells
por: Heizmann, Beate, et al.
Publicado: (2020)

Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells
por: Heizmann, Beate, et al.
Publicado: (2021)

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals
por: Heizmann, Beate, et al.
Publicado: (2013)

Ikaros controls isotype selection during immunoglobulin class switch recombination
por: Sellars, MacLean, et al.
Publicado: (2009)

Ikaros deficiency is associated with aggressive BCR-ABL1 B-cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin
por: Simand, Célestine, et al.
Publicado: (2021)

Ikaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation
por: Toubai, Tomomi, et al.
Publicado: (2015)

Differential regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros
por: Schjerven, Hilde, et al.
Publicado: (2013)

The Ikaros family of zinc-finger proteins
por: Fan, Yingzhi, et al.
Publicado: (2016)

Insights into Hox Protein Function from a Large Scale Combinatorial Analysis of Protein Domains
por: Merabet, Samir, et al.
Publicado: (2011)

Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase
por: Ma, Hong, et al.
Publicado: (2013)

An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities
por: Perotti, Elizabeth A., et al.
Publicado: (2015)

Ikaros Proteins in Tumor: Current Perspectives and New Developments
por: Xia, Ruolan, et al.
Publicado: (2021)

Four genetic lymphoma-specific events (MYC, BCL2, BCL6 and CCND1) identified in a high grade B lymphoma case
por: Ittel, A, et al.
Publicado: (2015)

Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice
por: Nichogiannopoulou, Aliki, et al.
Publicado: (1999)

Prognostic impact of Ikaros expression in lenalidomide-treated multiple myeloma
por: Krönke, Jan, et al.
Publicado: (2017)

Ikaros-Associated Diseases: From Mice to Humans and Back Again
por: Boast, Brigette, et al.
Publicado: (2021)

Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia
por: Kogut, Sophie, et al.
Publicado: (2022)

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros
por: Winandy, Susan, et al.
Publicado: (1999)

Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
por: Cytlak, Urszula, et al.
Publicado: (2018)

Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis
por: Nelson, Nadine, et al.
Publicado: (2015)

The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function
por: Seng, Amara, et al.
Publicado: (2017)

Transcriptional Regulation of Genes by Ikaros Tumor Suppressor in Acute Lymphoblastic Leukemia
por: Dhanyamraju, Pavan Kumar, et al.
Publicado: (2020)

IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?
por: Conserva, Maria Rosa, et al.
Publicado: (2023)

Multiple cytogenetics forms of KMT2A amplification and jumping translocation in a case of myelodysplastic syndrome
por: Ittel, Antoine, et al.
Publicado: (2021)

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
por: Alkhatib, Alabbas, et al.
Publicado: (2012)

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation
por: Bottardi, Stefania, et al.
Publicado: (2011)

The Combined Expression Patterns of Ikaros Isoforms Characterize Different Hematological Tumor Subtypes
por: Orozco, Carlos A., et al.
Publicado: (2013)

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor
por: Arenzana, Teresita L., et al.
Publicado: (2015)

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma
por: Georgopoulos, Katia
Publicado: (2017)

Ikaros expression is associated with an increased risk of chronic graft-versus-host disease
por: Pereira, A. D., et al.
Publicado: (2023)

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells
por: Stokes, Samuel, et al.
Publicado: (2020)

Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells
por: Anang, Vandana, et al.
Publicado: (2023)

A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic Cells
por: Beer, Philip A., et al.
Publicado: (2014)

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
por: Witkowski, Matthew T., et al.
Publicado: (2017)

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia
por: Song, C, et al.
Publicado: (2016)

Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia
por: Payne, Jonathon L, et al.
Publicado: (2020)

IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling
por: Lemarié, Maud, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b0aq565djmha5o9crof1o2e17b