Cargando…

Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis

Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significant...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jinlin, Zhou, Yonglie, Yu, Qinghua, Zhao, Zhao, Wang, Huan, Luo, Xiaoming, Chen, Yanxia, Zhu, Zhongliang, Chen, Guoqing, Wu, Mao, Qiu, Liannv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912309/
https://www.ncbi.nlm.nih.gov/pubmed/26559315
http://dx.doi.org/10.1097/MD.0000000000002061
_version_ 1782438249221849088
author Liu, Jinlin
Zhou, Yonglie
Yu, Qinghua
Zhao, Zhao
Wang, Huan
Luo, Xiaoming
Chen, Yanxia
Zhu, Zhongliang
Chen, Guoqing
Wu, Mao
Qiu, Liannv
author_facet Liu, Jinlin
Zhou, Yonglie
Yu, Qinghua
Zhao, Zhao
Wang, Huan
Luo, Xiaoming
Chen, Yanxia
Zhu, Zhongliang
Chen, Guoqing
Wu, Mao
Qiu, Liannv
author_sort Liu, Jinlin
collection PubMed
description Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significantly changed, but the CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cell subset might play an important role in the pathogenesis of IM.
format Online
Article
Text
id pubmed-4912309
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-49123092016-06-28 Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis Liu, Jinlin Zhou, Yonglie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Wu, Mao Qiu, Liannv Medicine (Baltimore) 3600 Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significantly changed, but the CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cell subset might play an important role in the pathogenesis of IM. Wolters Kluwer Health 2015-11-13 /pmc/articles/PMC4912309/ /pubmed/26559315 http://dx.doi.org/10.1097/MD.0000000000002061 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3600
Liu, Jinlin
Zhou, Yonglie
Yu, Qinghua
Zhao, Zhao
Wang, Huan
Luo, Xiaoming
Chen, Yanxia
Zhu, Zhongliang
Chen, Guoqing
Wu, Mao
Qiu, Liannv
Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title_full Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title_fullStr Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title_full_unstemmed Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title_short Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
title_sort higher frequency of cd4(+)cxcr5(+)icos(+)pd1(+) t follicular helper cells in patients with infectious mononucleosis
topic 3600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912309/
https://www.ncbi.nlm.nih.gov/pubmed/26559315
http://dx.doi.org/10.1097/MD.0000000000002061
work_keys_str_mv AT liujinlin higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT zhouyonglie higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT yuqinghua higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT zhaozhao higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT wanghuan higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT luoxiaoming higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT chenyanxia higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT zhuzhongliang higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT chenguoqing higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT wumao higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis
AT qiuliannv higherfrequencyofcd4cxcr5icospd1tfollicularhelpercellsinpatientswithinfectiousmononucleosis