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Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significant...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912309/ https://www.ncbi.nlm.nih.gov/pubmed/26559315 http://dx.doi.org/10.1097/MD.0000000000002061 |
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author | Liu, Jinlin Zhou, Yonglie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Wu, Mao Qiu, Liannv |
author_facet | Liu, Jinlin Zhou, Yonglie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Wu, Mao Qiu, Liannv |
author_sort | Liu, Jinlin |
collection | PubMed |
description | Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significantly changed, but the CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cell subset might play an important role in the pathogenesis of IM. |
format | Online Article Text |
id | pubmed-4912309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49123092016-06-28 Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis Liu, Jinlin Zhou, Yonglie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Wu, Mao Qiu, Liannv Medicine (Baltimore) 3600 Follicular helper T (Tfh) cells are recognized as a distinct CD4(+)helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4(+)CXCR5(+) Tfh cells were not significantly changed, but the CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4(+)CXCR5(+)ICOS(+)PD1(+) Tfh cell subset might play an important role in the pathogenesis of IM. Wolters Kluwer Health 2015-11-13 /pmc/articles/PMC4912309/ /pubmed/26559315 http://dx.doi.org/10.1097/MD.0000000000002061 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 3600 Liu, Jinlin Zhou, Yonglie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Wu, Mao Qiu, Liannv Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title | Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title_full | Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title_fullStr | Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title_full_unstemmed | Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title_short | Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis |
title_sort | higher frequency of cd4(+)cxcr5(+)icos(+)pd1(+) t follicular helper cells in patients with infectious mononucleosis |
topic | 3600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912309/ https://www.ncbi.nlm.nih.gov/pubmed/26559315 http://dx.doi.org/10.1097/MD.0000000000002061 |
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