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Dual role of GRK5 in cancer development and progression

GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several patho...

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Autores principales: Gambardella, J, Franco, A, Giudice, C Del, Fiordelisi, A, Cipolletta, E, Ciccarelli, M, Trimarco, B, Iaccarino, G, Sorriento, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università di Salerno 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912336/
https://www.ncbi.nlm.nih.gov/pubmed/27326393
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author Gambardella, J
Franco, A
Giudice, C Del
Fiordelisi, A
Cipolletta, E
Ciccarelli, M
Trimarco, B
Iaccarino, G
Sorriento, D
author_facet Gambardella, J
Franco, A
Giudice, C Del
Fiordelisi, A
Cipolletta, E
Ciccarelli, M
Trimarco, B
Iaccarino, G
Sorriento, D
author_sort Gambardella, J
collection PubMed
description GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions including cancer. Several reports underline the involvement of GRK5 in the regulation of tumor growth even if they appear controversial. Indeed, depending on its subcellular localization and on the type of cancer, GRK5 is able to both inhibit cancer progression, through the desensitization of GPCR and non GPCR-receptors (TSH, PGE2R, PDGFR), and induce tumor growth, acting on non-receptor substrates (p53, AUKA and NPM1). All these findings suggest that targeting GRK5 could be an useful anti-cancer strategy, for specific tumor types. In this review, we will discuss the different effects of this kinase in the induction and progression of tumorigenesis, the molecular mechanisms by which GRK5 exerts its effects, and the potential therapeutic strategies to modulate them.
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spelling pubmed-49123362016-06-20 Dual role of GRK5 in cancer development and progression Gambardella, J Franco, A Giudice, C Del Fiordelisi, A Cipolletta, E Ciccarelli, M Trimarco, B Iaccarino, G Sorriento, D Transl Med UniSa Articles GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions including cancer. Several reports underline the involvement of GRK5 in the regulation of tumor growth even if they appear controversial. Indeed, depending on its subcellular localization and on the type of cancer, GRK5 is able to both inhibit cancer progression, through the desensitization of GPCR and non GPCR-receptors (TSH, PGE2R, PDGFR), and induce tumor growth, acting on non-receptor substrates (p53, AUKA and NPM1). All these findings suggest that targeting GRK5 could be an useful anti-cancer strategy, for specific tumor types. In this review, we will discuss the different effects of this kinase in the induction and progression of tumorigenesis, the molecular mechanisms by which GRK5 exerts its effects, and the potential therapeutic strategies to modulate them. Università di Salerno 2016-05-16 /pmc/articles/PMC4912336/ /pubmed/27326393 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Gambardella, J
Franco, A
Giudice, C Del
Fiordelisi, A
Cipolletta, E
Ciccarelli, M
Trimarco, B
Iaccarino, G
Sorriento, D
Dual role of GRK5 in cancer development and progression
title Dual role of GRK5 in cancer development and progression
title_full Dual role of GRK5 in cancer development and progression
title_fullStr Dual role of GRK5 in cancer development and progression
title_full_unstemmed Dual role of GRK5 in cancer development and progression
title_short Dual role of GRK5 in cancer development and progression
title_sort dual role of grk5 in cancer development and progression
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912336/
https://www.ncbi.nlm.nih.gov/pubmed/27326393
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