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Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds
Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping, and a large sampling of compounds, it should be possible to identify compounds with desired mechanisms of action based on their behavioral pro...
Autores principales: | Bruni, Giancarlo, Rennekamp, Andrew J., Velenich, Andrea, McCarroll, Matthew, Gendelev, Leo, Fertsch, Ethan, Taylor, Jack, Lakhani, Parth, Lensen, Dennis, Evron, Tama, Lorello, Paul J., Huang, Xi-Ping, Kolczewski, Sabine, Carey, Galen, Caldarone, Barbara J., Prinssen, Eric, Roth, Bryan L., Keiser, Michael J., Peterson, Randall T., Kokel, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912417/ https://www.ncbi.nlm.nih.gov/pubmed/27239787 http://dx.doi.org/10.1038/nchembio.2097 |
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