Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and its related metabolic diseases. We identified PR domain containing 4 (Prdm4) induction by the small molecule butein as a means to induce uncoupling protein 1 expression, increase energy expe...

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Detalles Bibliográficos
Autores principales: Song, No-Joon, Choi, Seri, Rajbhandari, Prashant, Chang, Seo-Hyuk, Kim, Suji, Vergnes, Laurent, Kwon, So-Mi, Yoon, Jung-Hoon, Lee, Suk-Chan, Ku, Jin-Mo, Lee, Jeong-Soo, Reue, Karen, Koo, Seung-Hoi, Tontonoz, Peter, Park, Kye Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912433/
https://www.ncbi.nlm.nih.gov/pubmed/27159578
http://dx.doi.org/10.1038/nchembio.2081
Descripción
Sumario:Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and its related metabolic diseases. We identified PR domain containing 4 (Prdm4) induction by the small molecule butein as a means to induce uncoupling protein 1 expression, increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates white adipose tissue browning.

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